The twelth lecture in a series for the module Cells and Immunity. This lecture covers signalling in the immune system, chemokines, cytokines more. A great way to start your understanding of the module or to miss a lecture or two.
L12 – Signaling in the immune system
Definitions:
Cytokines (secreted proteins that mediate effector functions in the immune system – first
messengers)
Revision:
Types of receptors
Lecture:
Immune cell signaling basics
o Innate vs adaptive immunity
o PI3kinase and RAS kinase
Cytokines
o Function as ligand/receptors
o Families of cytokines
Chemokines (migratory towards infection)
Interferon (antiviral)
Interleukins (actions dependent upon interleukin)
o Classes of cytokines
Cytokines mediate innate immunity
Regulate lymphocyte growth, activation, and differentiation
Reg inflammatory cells
Mediate chemotaxis (attract neutrophils by IL-8 and eosinophils by IL5)
Causes immune cells to enter tissues from blood vessels
Stim hematopoiesis
o Innate immunity
Diff cells respond to diff factors
Eg IL-8 from macrophages act on NK cells and T cells
Pos/neg feedback groups in an autocrine loop
Can lead to cytokine storms that activate cells to damage normal
tissues (autoimmune)
o Adaptive immunity
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