Summary
Summary Schizophrenia A03 table
- Module
- Schizophrenia
- Institution
- AQA
A* NOTES!!! A clear, detailed and easy to read table of evaluation points for each A01 point within the topic. Clear PEA structure to gain top marks.
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Biological treatments for Schizophrenia- Thronley
- Compared side effects of
chlorpromazine, typical, with placebo.
Support for typical - 13 trils, 1100 participants.
- Overall association with better
functioning and reduced symptom
severity.
There is supporting evidence for typical antipsychotics in the biological treatment
for schizophrenia. Researcher Thornley investigated how chlorpromazine, or a
placebo drug impacted the side effects of schizophrenia. The meta-analysis of 13
studies, including over 1100 patients found that chlorpromazine was associated
with overall better functioning and reduced symptom severity, rather than the
placebo. This shows that antipsychotics are effective at treating schizophrenia
which has many benefits to the patients’ everyday lives, and creates a positive
stigma around chlorpromazine, to be prescribed to other patients.
- Meltzer
- Clozapine effective in 30-50% of
Support for atypical
treatment-resistant cases where typical
antipsychotics have failed.
there is supporting evidence for atypical psychotics being more successful than
typical antipsychotics as a biological treatment for schizophrenia. Researcher
Meltzer found that clozapine was effective in 30-50% of the treatment-resistant
cases where typical antipsychotics failed in reducing symptom severity.
- Cost-benefit analysis.
- Side effects and psychological
consequences.
Side effects
- Use of drugs is abused, USA hospitals
administer to make patients more
manageable.
-
- Original hypothesis not a complete
explanation.
- Dopamine levels in places other than
subcortex were too low, not too high.
Issues with dopamine hypothesis - Antipsychotics work to reduce
dopamine levels.
- Modern understanding means
antipsychotics shouldn’t work –
undermines public faith in them.
-
- Healy
Issues with supports evidence - Successful trials were published
multiple times.
-
Psychological explanations for Schizophrenia
- Read – 46 studies of child abuse
- 69% female inpatients had history of
Support for family dysfunction
physical, sexual abuse or both.
- Man – 59%.
Ethical issues and weak evidence for - Little evidence supporting
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