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Robbins Pathology Summary - Tuberculosis
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This document contains summary of Robbins Pathological Basic of Disease on Tuberculosis. It is filled with illustrative diagrams and excellent handwriting
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Test Bank for Robbins Basic Pathology 11th Edition by Vinay Kumar, Abul K. Abba Chapters 1 - 24
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Test Bank for Robbins Basic Pathology 10th Edition by Vinay Kumar, Abul K. Abba & Jon C. Aster|9780323353175| All Chapters 1-24|LATEST
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Test Bank for Robbins Basic Pathology 10th Edition by Vinay Kumar, Abul K. Abba & Jon C. Aster
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TUBERCULOSISTuberculosis is a chronic
granulomatous disorder caused
Etiology
by:
Mycobacterium Tuberculosis M. tuberculosis M. bovis
Mycobacterium Bovis
Transmitted by: Spread through
unpasteurized
Mycobacterium milk
Tuberculosis Aerosol transmission
from infected
It is an acid-fast bacilli humans
Acid-fastness is due to Risk Factors
presence of mycolic acids
Weakly gram-positive For Infection For
Transmission
Mycosides
Immunocompromised
Mycolic acid state
Young females
Arabinogalactan Old males
LAM
Sputum +ve patient
Plasma Membrane Overcrowding
Miliary TB
, Pathogenesis: Inhibition of phagosome-
lysosome fusion
CMI plays an important role
in the pathogenesis of
tuberculosis
Bacilli
Before Activation of CMI proliferates
inside
Bacilli enter lungs via the macrophage
aerosol route
LAM of bacilli bind to Rupture of macrophages
Mannose-binding receptor
of alveolar macropahges Bacteremia
Seeding to multiple sides
This process occurs for
3 weeks after entry
Patient is asymptomatic
at this stage
LAM activate Coronins
Activate phosphatase-
calcineurin
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