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Metabolism of Carbohydrates

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This document describes the basic metabolic pathways associated with the carbohydrates such as glycolysis, gluconeogenesis, glycogenolysis, etc.

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  • October 1, 2022
  • 27
  • 2019/2020
  • Other
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Metabolic Pathways of
Carbohydrates



By



Hasnat Mueen




1

, Contents
1 Introduction: ....................................................................................................................... 1

2 Glycolysis: ......................................................................................................................... 2

2.1 Significance: ................................................................................................................ 2

2.2 Types of Glycolysis (and net ATPs): .......................................................................... 2

2.2.1 Aerobic glycolysis: .............................................................................................. 3

2.2.2 Anaerobic glycolysis:........................................................................................... 3

2.3 Reactions of Glycolysis:.............................................................................................. 3

2.3.1 Energy investment phase: .................................................................................... 3

2.3.2 Splitting phase:..................................................................................................... 4

2.3.3 Energy generation phase: ..................................................................................... 5

2.4 Fate of pyruvate:.......................................................................................................... 6

3 Tricarboxylic Acid Cycle (Kreb’s Cycle or Citric Acid Cycle): ....................................... 7

3.1 Sources of Precursor of Acetyl CoA: .......................................................................... 8

3.2 Important Steps of TCA cycle:.................................................................................... 8

3.3 Electron Transport Chain: ........................................................................................... 9

4 Gluconeogenensis: ........................................................................................................... 10

4.1 Importance:................................................................................................................ 10

4.2 Substrates: ................................................................................................................. 10

4.3 Reactions of gluconeogenesis: .................................................................................. 11

4.3.1 Conversion of pyruvate to phosphoenolpyruvate: ............................................. 11

4.3.2 Conversion of fructose 1,6-bisphosphate to fructose 6-phosphate: ................... 12

4.3.3 Conversion of glucose 6-phosphate to glucose .................................................. 12

4.4 Gluconeogenesis from amino acids: ......................................................................... 12

4.5 Gluconeogenesis from glycerol:................................................................................ 12

4.6 Gluconeogenesis from lactate (Cori cycle): .............................................................. 12

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, 5 Glycogenesis: ................................................................................................................... 13

5.1 Steps of Glycogenesis: .............................................................................................. 13

5.1.1 Synthesis of UDP glucose:................................................................................. 13

5.1.2 Synthesis of primer to initiate glycogenesis: ..................................................... 13

5.1.3 Glycogen synthesis by glycogen synthase: ........................................................ 14

5.1.4 Branch Formation: ............................................................................................. 14

6 Glycogenolysis:................................................................................................................ 14

6.1 Steps of glycogenolysis: ............................................................................................ 14

6.1.1 Shortening of Glycogen chain: .......................................................................... 15

6.1.2 Removal of branches: ........................................................................................ 16

6.1.3 Formation of glucose 6-phosphate and glucose: ................................................ 16

7 Pentose Phosphate Pathway: ............................................................................................ 16

7.1 Importance:................................................................................................................ 17

7.2 Various reactions in HMP pathway: ......................................................................... 17

8 Glucuronic Acid Pathway: ............................................................................................... 18

8.1 Various involved steps/reactions:.............................................................................. 18

9 Galactose metabolism: ..................................................................................................... 19

10 Fructose Metabolism:....................................................................................................... 20

10.1 Fructokinase pathway: ........................................................................................... 20

10.2 Sorbitol pathway of fructose production: .............................................................. 21

11 Metabolism of Amino sugars: .......................................................................................... 22

12 Glyoxylate Cycle: ............................................................................................................ 22

12.1 Reactions of the Cycle: .......................................................................................... 23

13 References: ....................................................................................................................... 24




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