Exam (elaborations)
Cell Biology 2015 Exam Paper
- Module
- Cell Biology
- Institution
- Imperial College London (ICL)
Cell Biology 2015 Exam Paper
[Show more]
Content preview
Q1: Describe how activation of G-protein-coupled receptors activates the inositol phospholipidsignalling pathway which in turn activates protein kinase C
Q2: Discuss the role of SH2 domains in signal transduction downstream of receptor tyrosine
kinases and cytokine receptors.
Q3
Assume T = 310 K R = 8.314 J K-1mol-1 F = 96, 400 C mol-1
Intracellular & extracellular ion concentrations
Ion Inside Outside
Sodium 14 mM 125 mM
Potassium 124 mM 5 mM
Chloride 6 mM 77 mM
Discuss the factors that determine the values of the following membrane potentials:
a) The resting membrane potential (2 marks)
b) The peak of the action potential (2 marks)
c) The threshold for firing an action potential (2 marks)
d) The extent of hyperpolarization immediately following an action potential (2 marks)
How would each of these membrane potentials change if:
i) The external potassium ion concentration was halved (2 marks)
ii) The external sodium ion concentration was increased by 25% (2 marks)
iii) The rate of sodium channel inactivation was reduced (2 marks)
iv) The nerve axon was exposed to a low concentration of tetrodotoxin (2 marks)
Where appropriate, use accurate sketches of the action potential to illustrate your answer
and, where possible, calculate values for the changes in membrane potential.
Q4: Long-term potentiation (LTP) is considered a likely process for how memories are formed at
the synaptic level. Why? (50%) What kind of experiments have been done in support of this
statement? (50%)
Q5. How does an induced pluripotent stem cell (iPSC) differ from other types of stem cells? (60%)
Describe how iPSCs can help us understand and possibly treat disease in one named organ. (40%)
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller christyau. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £4.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
70055 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now