Nucleic acid synthesis inhibitors: inhibition of base formation and blocking of DNA
coiling. Energy (ATP) required for repair also causes cell exhaustion.
Are orally active and bacteriostatic drugs
Their action is prevented by pus
Widespread resistance to hospital acquired infections
S/Es: nausea, vomiting, bone marrow suppression due to hypersensitivity
Have largely been replaced by anti-microbials with less resistance and toxicity
Effective against Streptococcus pneumoniae and Haemophilus influenza
Can be used prophylactically against TB in HIV
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