Exam (elaborations)
CLINICAL PHARMACOLOGY practice questions
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practice questions- systems based approach(CLINICAL PHARMACOLOGY)
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Clinical Pharmacology1. Which one of the following statements is 3. Acetaminophen toxicity has a unique
TRUE regarding the biotransformation of pathway involving biotransformation in
drugs: the liver. Which of the following
a) Cigarette smoke and chronic statements is FALSE regarding
alcohol consumption induce P450 acetaminophen toxicity?
enzymes a) Chronic alcohol use increases risk of
b) Phase I reactions increase the lipid hepatocellular damage because of
solubility of drugs CYP2E1 induction which increase
c) Phenytoin (DilantinTM) is a potent toxic metabolites (NAPQI)
P450 enzyme inhibitor b) N-acetylcysteine is the primary
d) Phase II reactions decrease the therapy used in treatment of patients
water solubility of drugs with acetaminophen toxicity
e) Biotransformation is increased in c) Acute alcohol use increases risk of
the elderly hepatocellular damage because it
induces CYP2E1, thereby increasing
2. Tamoxifen, a popular drug used in the build up for toxic metabolite (NAPQI)
treatment of estrogen receptor positive d) Glutathione repletion is the most
breast cancer, is metabolized through the commonly used treatment in
Cytochrome P450 pathway (CYP2D6). addressing Acetaminophen toxicity
Codeine, an opioid analgesic is also
metabolized through the CYP2D6 4. Which of the following statement is
pathway. Using knowledge of Genetic FALSE with respect to
Polymorphisms, which of the following pharmacodynamics?
examples would predict clinical response a) Efficacy is a measure of the ability of
in a patient who is a poor metabolizer at a drug to elicit an effect at its
the CYP2D6 pathway? receptor
b) Potency is a concentration of a drug
a) Increased clinical effect of needed to elicit a given effect
Tamoxifen and Codeine c) Agonists are drugs that bind to
b) Increased clinical effect of endogenous ligands and exert an
Tamoxifen, poor clinical effect of effect
Codeine d) A partial agonist can be made into
c) Decreased clinical effect of full agonist by increasing its
Tamoxifen and Codeine concentration
d) Decreased clinical effect of e) Antagonists are drugs that have
Tamoxifen, increased clinical effect affinity for its receptor, but no efficacy
of Codeine
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