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Lecture notes 7PAYFADD; PSYCHOLOGY & NEUROSCIENCE OF ADDICTION, week 1, topic 3 £4.49   Add to cart
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Lecture notes 7PAYFADD; PSYCHOLOGY & NEUROSCIENCE OF ADDICTION, week 1, topic 3
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Detailed summary lecture notes for week 1, topic 3, risk factors for addiction, in the 7PAYFADD; PSYCHOLOGY & NEUROSCIENCE OF ADDICTION module at King's college London.

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  • November 19, 2022
  • 3
  • 2021/2022
  • Lecture notes
  • Michael lynskey
  • All classes

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W1 T3; Risk factors for addiction


Genes
 Last 20 years have been progress in identifying specific gene variants
 Articles are misleading, as there is no one gene for addiction or dependence
 Complex behaviours are influenced by many genes, with individual risk low
(heterogeneity)
 A number of genes have been associated below with alcohol and nicotine
dependence but all have very low risk





 For cannabis dependence, a number of candidates proposed





 So far, little replication of results; meta analysis of cannabis gwas and gene based
association tests found no significant SNP (Agrawal et al, 2011)
 Another gwas of cannabis dep with dsm diagnosis found no snp (Agrawal, 2014)


Addiction is multi stage
 Most studies compare drug users and non drug users, which confounds early stage
of dependence; could have different genetic influence at different stages e.g.
personality traits for nonconformity
 Later stages could be influenced by genes for drug metabolism
 Studies may need to look at just one stage such as initiation to identify variants

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