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Lecture notes 7PAYFADD; PSYCHOLOGY & NEUROSCIENCE OF ADDICTION, week 1, topic 2 £5.49   Add to cart
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Lecture notes 7PAYFADD; PSYCHOLOGY & NEUROSCIENCE OF ADDICTION, week 1, topic 2
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Detailed summary notes for week 2 topic 2 (pharmacokinetics and pharmacodynamics) of the 7PAYFADD; PSYCHOLOGY & NEUROSCIENCE OF ADDICTION module at King's college London .

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  • November 21, 2022
  • 6
  • 2021/2022
  • Lecture notes
  • Martin broadstock
  • All classes

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W2 T2; Pharmacokinetics and pharmacodynamics
 Psychopharmacology – how drugs change mood, cognition and behaviour
 Our focus is psychoactive drugs that affect CNS; therapeutic use (anti-epileptic) and
recreational (addiction)
 Current lack of understanding on MOA; synapse level understanding but not whole
brain
 Neuronal network and receptor interactions are complex so add to difficulty


Pharmacokinetics
 What our body does to drugs
 These parameters affect drug use:
o A – administration/absorption
o D – distribution
o M – metabolism
o E – extraction



Administration
 Method of taking drug:
o Oral (tablet)
o Injection; intramuscularly (IM), intravenously (IV) and subcutaneous (SC)
o Inhalation
o Application to skin
o Mucous membranes; intranasal (snorting), sublingual (under tongue)

 Route of admin depends on chemical characteristics of drug, personal preference,
how long drug remains in body and dosage (concentration profile)
 E.g. below shows different peaks, concentration and duration





 Absorption is how quickly drug can pass cellular barrier into blood stream
 IV is fastest as it is direct; in all the rest, need to cross at least one cellular membrane

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