Detailed summary notes for week 2 topic 1 (biological basis of addiction) of the 7PAYFADD; PSYCHOLOGY & NEUROSCIENCE OF ADDICTION module at King's college London .
W2 T1; Biological basis of addiction
We will cover reward pathway, NTs, how drugs hijack this and withdrawal
Concepts; addiction cycle and reward pathway
This is the general addiction cycle; after binge intoxication, negative withdrawal
effects occur and preoccupation anticipation of getting the substance
The reward pathway is a complex network of axons activated by food, sex, exercise,
risky behaviour; these are evolutionary advantageous to individual or species
Action of the pathway dependant on dopamine modulation
Drugs of abuse hijack reward pathway, giving the good feeling
Reward pathway shown below; VTA connects to PFC and NAC; affects higher func
like planning
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