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Lecture notes

Acute and Chronic Myeloid Leukaemia

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This document contains all the essential knowledge pertaining to myeloid leakage is needed for student level. It includes: Pathophysiology Symptoms Diagnosis Treatment

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  • December 18, 2022
  • 4
  • 2022/2023
  • Lecture notes
  • Caitlin austin
  • All classes
All documents for this subject (59)
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caustin2536
Pathophysiology
Accumlation of myeloid blasts unable to differentiate into mature
neutrophils rbc or platelets results in bone marrow failure Definitive
diagnosis is 120 blasts of myeloid lineage on bone marrow peripheral
blood smear This will also distinguish AML for ALL


Signs symptoms
Fatigue dizziness palpitations pallor Anaemia I RBC
Mucousal bleeding bruising menorrhagia Thrombocytopenia

Signs of infection

Investigations
FBC I Hb RBC T WCC I neut I platelets
Peripheral blood smear Myeloid blasts 220 on blood
film presence of Auer rods or Phi bodies
Coagulationpanel May be
normal or show Dlc
prolonged
DT APPT and I
fibrinogen
Flow cytometry Great to
distinguish AML from ALL AML
typing is negative for Tdt and positive for myelo
peroxidase All is the opposite
HLA
antigentyping Allogenic stem cell transplant

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