During inspiration, the cause of contraction of the inspiratory muscles is
stimulation from the phrenic (C3-C5) and external intercostal (T1-11)
nerves.
Respiratory rhythm is generated in the medulla and the pons.
APNEUSTIC CENTRE
Located in the pons and causes you to breathe
in.
Produces tonic (long-lasting) stimulation of
inspiration which is inhibited by pulmonary
stretch receptors and by pneumotaxic centre.
PNEUMOTAXIC CENTRE
Located in the pons.
Stimulated by apneustic centre and outflow
from inspiratory neurones.
Activity of these centres facilitates the
transition from inspiration to expiration.
Hering-Breuer Reflex – stretch receptor – inhibits apneustic centre and
inspiratory neurones in the medulla.
When the apneustic centre causes you to breathe in, stretch receptors in
the lung send action potentials up the vagal nerve which inhibit inspiratory
neurones in the lung and the apneustic centre. In doing so, they inhibit the
respiratory drive.
Pneumotaxic centre is then stimulated, and inhibits the apneustic centre
stopping you from breathing in. Therefore, the pneumotaxic centre starts
to stop as it is inhibiting the apneustic centre and the pneumotaxic centre
drive depends on the stimulation of the apneustic centre; so you get a
negative feedback loop.
If spinal cord is shattered below the medulla then you won’t get any
respiratory action as both the medulla and the pons have been cut off.
Sleep Apnea (Ondine’s Curse)
Basic respiratory generator no longer exists.
Apnea – lack of breathing.
Patients have to remember to breathe consciously in the day and
have to be on a ventilator overnight.
Where are chemoreceptors located?
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller harrykane. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £2.99. You're not tied to anything after your purchase.