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Cardiovascular Summary BVM2 RVC £9.99   Add to cart

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Cardiovascular Summary BVM2 RVC

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A summarised booklet of all the cardiovascular lectures in second year veterinary medicine at the RVC. Each summary covers the learning objectives provided by lecturers in a clear and concise manner including helpful diagrams.

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  • March 15, 2023
  • 8
  • 2020/2021
  • Summary
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saskiachelliah
PREIOAD Caving pressure) CHRONOTROPY cheat rate )
Determinants are cardiac output : ionic basis of pacemaker action p




yµ µ 1g
4. heart rate 9 . Slow depolar

↳ decrease
2. myocardial connectivity

3. Preload increase

4 . Afterload
I ↳ increase

2.
Voltage gated Ca channels open


Preload →
pressure snatching cardiac muscle ↳ Ca moves in → more voltage
during timing .
cntdnnels ac

Frank starving law → energy of contraction of cardiac muscle 3 .
Depolarisation of K

fibre initial fibre nest
↳ K moves out
relationship a
length at
.
.




between VEDV

increased ventricular end diastolic volume Ionic basis of ventricular action p
>
2




µ |g
- 0
e. sv .
↳ increased exposure of myosin heads .
Rapid depola

↳ force
increased one connection .




' '
Venous Return → rate of blood flow back to heart . 9 . Notch → d
4 4
↳ some
Factors -1


Affecting Venous Return : -
K

' '
^
Volume of blood 2 . Plateau

2. Distribution of blood ↳ slow inward current → L t

3. Gravity t movement ↳ outward K current .




4 . Venous tone (sympathetic nerve activity) 3 . Repatriation

Reflex Responses : ↳ inward channels deac

-


Hypervotdemird (4 blood volume ) ↳ outward K channel dom

↳ ' '
Arterial barovecepiov mlllex -


Depressor velvet Regulation of Heart Rate by Autonom


decreases sympathetic outflow Parasympathetic : VAGUS NERVE → S

↳ outflow ↳ Acn
increases parasympathetic .
release ↳ at re

↳ ↳ opens fewer
Ariel receptors the channels -
slow

↳ Inhibit sympathetic vasconsricwrp.am to kidneys .
Sympathetic :
ADRENERGIC FIBRES →



Inhibits ADH secretion from post pituitary.
.

release noradrenaline (nonepin

Hypothermia ( t ) ↳
-


blood volume more Na channels
opens
-




'
↳ Arterial Baronecepwr Reflex - Presser ' neliex .





increases sympathetic outflow SYMP : Effects of Norepinephrin

↳ decreases parasympathetic outflow .
↳ NAD →
By aarenoreceptors →



↳ ↳
Atrial Receptors No channels activated earlie

↳ More
to
kidneys CRAAS) phosphoryl
↳ increase sympathetic pathway ca channels

↳ increase ADH from ↳ K
secretion post pituitary
-
. channels activated earlie


Atrial Natriunehc Peptide CAMP) defends against Vol overload -
:
=
Increased HR .




-

released in response to aerial pressure increase (arterial stretch ) PARA : Effects of Acn via vagus

Nat Mz (muscarinic)

stimulates excretion of Hzot ↳ Ach → receptors

↳ Vasodilation (by stimulating comp) ↳ Ach → M2 receptor → 6k → Kt
↳ ↳
inhibits RAAS .




=
Decreased HR .




(WOTROPT fsnengm of connection at a given EDV ) origin of EC6 main features :

Intracellular Cd regulates cardiac contractility : P wave = Atrial depolarisation

connection; qpg comp, = ✓ enn.am depolarisa

-

ca enters an via L type voltage sensitive channels .

T wave -- Ventricular nepoiansavion .




Ca induced Ca release from sarcoplasmic reticulum(via RyR2)
-

-




Cd binds to Troponin C connection Excessive
-



= .
HRS can compromise car

Relaxation: 9 HR (tachycardia) → inadequate

Remove elevated Ca ↳
hyp
:
long term :
-




7. Ca pump -

energy dependant 1 HR (bradycardia → decreased

, AFTERLOAD ( peak ventricular tension during systole ,
determined
by MAP)

MAP = Cox TPR


Afterload → amount of resistance heart must overcome to open aortic valve t expel blood .




Factors that influence Arterial Blood pressure :


Physical Factors :




9. Blood volume

2 . Arterial Compliance


Physiological Factors :




7 .
Cardiac output

2. Total peripheral resistance .




Age , gender , disease, postne eat . . .




Baronecaptors in the reflex control of Arterial Blood pressure:

Baronecaptors in Carotid sinus, root of Aortic Arch .




Chernoreceptovs in cavon.at Aortic bodies .





depressor Ipnessor reflex .




pressure increase →
artery diameter increase → baronecepwrssnetchctumcaadvenn.me) → ap discharge →


Mechanisms regulating vascular tone:

a. Metabolic -

Oz cone . CK02 =
vasodilation )
2. Neural -
a adnenoneceptors = vasoconstriction


Bz daren receptors = vasodilation .




3. Hormonal -
epinephrine Inonepinephnine , angiotensin 11 , ADH = Vasoconstriction .




ANP , histamine vasodilation
-

.




4. Endothelial -
Nine oxide = vasodilation .




Lymph Formation :

starting forces move fluid into capillary bed
Opposing .




xs fluid which is not reabsorbed →
lymphatic vessels back to Cvs .

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