Lecture notes
virus replication
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this document is about virology it cover general view of virus replication of different viruses including all single stranded and double stranded DNA viruses
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REPLICATION OFVIRUS
Dr. Moto
,Virus (Latin, poison)
Viruses are sub-cellular, non-living, infectious
entities which only become part of a living system
when they have infected host cells, a form of
borrowed life (van Regenmortel, 2000)
Viruses are obligate intracellular parasites.
They need the help of a host cell for
their replication.
All viruses have to penetrate, replicate & come out
of a cell.
Infection of a cell by virus may result in various
types of infection.
,
, Stages of virus replication
Phase– I Initiation: This stage is characterized by
introduction of genetic material of the virus into the cell.
• Attachment
• Penetration
• Uncoating
Phase – II Replication: This stage is characterized by the
genome size, composition and organization of viruses. There
is no single pattern of replication. But all make proteins with 3
sets of functions to:
•Ensure replication of the genome
•Package the genome into virus particles
•Alter the metabolism of the infected cell so that viruses are
produced.
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