BIOLOGICAL SCIENCES Paper A1
(BIOL 201) (3 hours)
___________________________________________________________
Answer ALL parts of Section A in one answer booklet . Answer ONE question from
Section B and ONE question from Section C in 2 separate answer booklets. All parts
of Section A are equally weighted. Sections A, B and C also carry equal weighting.
Section A - BIOL201 Biochemistry (answer all five questions)
1. How is glucose made available from our dietary carbohydrates and how is it
absorbed into the bloodstream?
2. Using diagrams, illustrate electron transport through complex III of the
respiratory chain.
3. Write brief notes on the structure and function in metabolism of the co-enzymes
NAD+ and NADP.
4. Briefly describe clinical interventions which may be used to prevent a thrombosis
or remove a pathological clot which has formed.
5. Outline how the enzyme acetyl-CoA carboxylase is regulated during fatty acid
biosynthesis.
Section B - BIOL201 Biochemistry (answer one question only)
6. Using suitable examples, explain how control can be achieved in the metabolic
pathways involved in glucose homeostasis.
7. Discuss how different experimental approaches can be used to study enzyme
structure, activity, mechanism, and regulation.
8. Following tissue damage thrombin is produced but it has a strong positive
feedback effect upon the production of further thrombin molecules. Discuss how
the uncontrolled generation of active thrombin and hence formation of fibrin clots
is prevented.
Continues over
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