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Summary Unit 1: Principles of drug action
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To explain and demonstrate the principles of how drugs act in the body (pharmacodynamics), how the body acts on drugs (pharmacokinetics) and the origin of unwanted effects (adverse drug reactions and drug toxicity). Along with this, fundamental terminology, interaction and relationship between agon...

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  • May 1, 2023
  • 32
  • 2022/2023
  • Summary

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Principle of Pharmacology
taught

Rep 1

Rep 2

Rep 3

Status




Unit 1: Principles of Drug Action
Agonists
definition

affinity
the ability or tendency of an agonist to bind to a receptor to form a complex,
quantified by the affinity constant (KA), represent the likely hood of a Drug-
receptor complex forming
higher the affinity, lower ka



efficacy
the ability of an agonist to produce a biological effect




Principle of Pharmacology 1

, potency
a measure of the concentrations of a drug at which is effective



EC50 (C for concentration)
the effective concentration of an agonist which produce 50% of the maximum
possible response
(conc. at 50% response)



ED50 (D for dose)
the effective dose of an agonist which produce 50% of the maximum possible
response

(dose at 50% response)



full agonist and partial agonist




Principle of Pharmacology 2

, to note: no matter how high conc of partial agonist, cannot produce maximal
activation



inverse agonist

drug produce an effect opposite to that agonist, but compete for same receptor,
have -ve efficacy
e.g. antihistamines to histamine H1 receptor




Principle of Pharmacology 3

, pharmacodynamics

(the action of drug on the body, inhibit or enhance)

the effect a drug has on the body enables an appropriate choice of therapeutic
tool



pharmacokinetics
(the action of the body on drug, ADME)

what the body reacts to a drug enables an appropriate dose rate to be selected,
which varies across species



Know how agonists interact with target molecules and the relationship between
concentration and response;

Explain the following terms: affinity, efficacy, potency, EC50 and ED50, spare
receptor hypothesis;




Principle of Pharmacology 4

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