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NR 565 Week 4, Study Guides, NR 565: Advanced Pharmacology Fundamentals, Chamberlain
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NR 565 Week 4, Study Guides, NR 565: Advanced Pharmacology Fundamentals, Chamberlain
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NR 565 Week 4 Study Guide,Chapter 15: Drugs Affecting the Central Nervous System
Anorexiants (p. 226): Short-term adjuncts to calorie limiting, cognitive-behavioral,
weight-loss programs for severely obese individuals. Nonamphetamine appetite
suppressants are commonly used today but are chemically and pharmacologically related
to amphetamines. (Phendimetrazine, Benzphetamine, Diethylpropion HCl, Phentermine,
Lorcaserin)
Precautions and Contraindications: High risk of tolerance and dependence. Should be
used in caution with patients who have a history of alcohol or drug dependence. Use
should be limited to 6 months and discontinued at any sign of tolerance.
Substance Abuse: Patients who abuse substances such as cocaine, phencyclidine,
and methamphetamine should not be prescribed anorexiants because of the
potential for excessive adrenergic stimulation.
Alcoholics: Actively drinking alcoholics taking anorexiants have experienced
depression, paranoia, and psychosis.
Diabetes: Patients with diabetes may experiences altered insulin or oral
hypoglycemic dosage requirements.
Lorcaserin: Serotonergic drug. Patients may develop serotonin syndrome or
Neuroleptic Malignant Syndrome like reactions if coadministered with
serotonergic drugs. Pregnancy Category X and is not approved in children under
18.
Anticonvulsants (p. 227):
Hydantoins: First line treatment of choice for tonic-clonic and partial complex seizures
and the lease sedating drugs used to treat seizure disorders of any type. (phenytoin-
Dilantin, ethotoin-Peganone, fosphenytoin-Cerebyx).
Pharmacodynamics: Inhibit and stabilize electrical discharges in the motor cortex
of the brain by affecting the influx of sodium ions into the neuron during
,depolarization and repolarization, slowing the propagation and spread of
abnormal discharges.
Metabolism and Excretion: Metabolism takes place in the liver and
excretion via the kidneys. Plasma half-lives range from 6-24 hours.
Precautions and Contraindications: Contraindicated under conditions of
hypersensitivity. Phenytoin induced hepatitis is a common hypersensitivity
reaction. Other hypersensitivity reactions include fever, rash, arthralgias, and
lymphadenopathy.
Phenytoin: May cause severe cardiovascular events and death has resulted
from too-rapid IV administration. Phenytoin has a Black-Box Warning
that IV administration should not exceed 50mg/minute in adults and 1-3
mg/kg/minute in pediatric patients owing to risk of cardiovascular
reactions associated with a too rapid rate of administration.
Contraindicated in sinus bradycardia, sinoatrial block, second-and third-
degree AV block, and Stokes-Adams syndrome. Should be used
cautiously in patients with hepatic or renal disease.
Ethotoin: Contraindicated in the presence of hepatic or hematological
disorders.
Fetal Defects: Pregnancy Category D. About 10% of babies have defects
in Mother’s who take phenytoin during pregnancy. Newborns exposed to
phenytoin is utero may experience decreased levels of Vitamin K-
dependent clotting factors and the mother should receive Vitamin K before
delivery and the newborn at birth.
Adverse Drug Reactions: CNS effects (agitation, ataxia, confusion, dizziness,
drowsiness, headache, and nystagmus), Cardiovascular effects (hypotension,
tachycardia, atrial and ventricular conduction depression, and ventricular
fibrillation), GI effects (nausea, vomiting, anorexia, altered taste, constipation, dry
mouth, and gingival hyperplasia), GU effects (urinary retention and reddish-
brown discoloration of urine), Dermatologic reactions (Stevens-Johnson
Syndrome and toxic epidermal necrolysis).
Drug Interactions: Interactions that increase hydantoins effect because of
, increased metabolism, competition for binding sites or for unknown reasons occur
with benzodiazepines, cimetidine, disulfiram, TCAs, salicylates, and valproic
acid. Interactions that decrease hydantoin’s effect include barbiturates, rifampin,
theophylline, influenza vaccine, pyridoxine, and antacids. Oral contraceptives
effect is decreased with use of hydantoins. Acute alcohol intake may increase
phenytoin serum levels, whereas chronic alcohol use may decrease levels. IV
phenytoin should only be mixed with normal saline.
Monitoring: Patients should be assessed for phenytoin hypersensitivity syndrome
(fever, skin rash, lymphadenopathy), which usually occurs at 3-8 weeks. Baseline
CBC, urinalysis, and LFTs should be assessed prior to onset of treatment, with
frequent reassessment during the first few months of treatment. Plasma levels
should be monitored, especially when drugs that increase plasma hydantoin, such
as ibuprofen, are used.
Patient Education: Abrupt withdrawal may lead to status epilepticus. Advise the
patient to wear a medical identification bracelet, to avoid hazardous situations if
drowsiness occurs, and to report adverse effects to the clinician. Patients should
avoid alcohol use. Maintain good oral hygiene to prevent tenderness, bleeding,
and gingival hyperplasia. Phenytoin may color the urine red, pink, or reddish
brown but the color change is not a cause for alarm. Advise diabetic patients to
monitor blood glucose levels and report significant changes to the clinician.
Iminostilbenes (p. 235): (Carbamazepine-Tegretol and oxcarbazepine-Trileptal).
Structurally related to TCAs. Used to treat epilepsy, bipolar affective disorder, aggressive
and assaultive behavior, and some neuralgias.
Pharmacodynamics: Thought to affect the sodium channels, slowing influx of
sodium in the cortical neurons and slowing the spread of abnormal activity.
Carbamazepine exerts its effect by depressing transmission in the nucleus
ventralis anterior of the thalamus. This area is associated with the spread of
seizure discharge.
Metabolism and Excretion: Carbamazepine is metabolized in the liver and
has the unique ability to induce its own metabolism (autoinduction). Due
to autoinduction, initial concentrations within a therapeutic range may
later fall despite good compliance. It also induces the metabolism of many
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