Summary
Summary Sterilisation kinetics
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- University Of East Anglia
Industrial pharmacy - 1st semester Includes bullet points, key diagrams and images
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Sterilisation Kinetics All follow first order kinetics
Rate of death at a specific time is dependant on the number of micro-organisms
present
Kinetics
N0=number of microbes present at t=0
Nt=number of microbes present at t
First order decay dN/dt=-constantxN 0
log(Nt)=log(N0)-kxt (k=constant/2.303)
k is a specific value for each microbe at each temperature
Half Life
Must have t=t1/2 and Nt=0.5xN0
t1/2=0.301/k and is independent of N0
Decimal Reduction Time (D)
D is the time to reduce the bioburden to 10% of its initial value (in minutes)
t=t0.1 which is D and Nt=0.1xN0
D=1/k
D is independent of N0
D value is related to particular micro-organism and temperature
At 121o D tends to be between 0.5-2 minutes
D can predict how long it will take to reduce the number of micro-organisms to a
specific level or by a specific amount
Temperatures Effect on D
As temperature increases D decreases (not linear)
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