Summary
Summary Mycology in pharmaceutics
- Institution
- University Of East Anglia
Industrial pharmacy - 1st semester Includes bullet points, key diagrams and images
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MycologyStructure
Composed of filaments called hyphae
May contain internal cross-walls called septa which can allow cytoplasm to flow
between cells
Chitin cell wall- β 1-3 and β 1-6 linked glucans and chitin
Unique lysine synthesis AAA pathway (aminoadipic acid pathway)
Cell membranes contain ergosterol
Store glucose as glycogen
Haploid cells
Sexual and asexual reproduction
Zygomycota
Soil dwelling fungi
Mucormycosis infection common in patients with- diabetes, cancer or
leukaemia
Ascomyota
Important for antibiotic production
Pulmonary infections in people with underlying lung disease
Also aflatoxins which can cause an allergic response
Can causal oral infections
Can kill those who are immunocomprimised
Basidiomycota
Toxic mushrooms can produce alpha amanitin
Death cap causes most fatalities
Infections In Humans
Ringworm, athletes foot and thrush
Found fungi that can produce diosgenin which can be converted to cortisone
Ergot alkaloids can be used as vasoconstrictors for migraines and womb
contractions
Ephedrine is used to treat asthma
Also produce citric acid and ethanol
Biological Control Agents
Using one organism to control another (pesticides)
Success limited by ability to control a narrow range of pests, slow action and
short field life
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