Summary
Summary Steroid medicinal chemistry
- Institution
- University Of East Anglia
Neurophysiology, synaptic pharmacology and endocrinology - 2nd semester Includes bullet points, key diagrams and images
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Steroid Med ChemStructure
A/B, B/C and C/D are trans fused
4,5 or 5,6 can be unsaturated
Oestrogens A ring id aromatic
α substituents are on the lower face (dash) and β are on the upper face (solid)
Biosynthesise of Steroids
1. Synthesis of mevalonate from acetyl CoA
2. Synthesis of IPP
3. Synthesis of squalene from IPP
4. Cyclisation of squalene to form lanosterol
5. Synthesis of cholesterol from lanosterol
Step 1
, Step 2
Di-phosphorylation of tertiary alcohol to give IPP
Step 3
DPP isomerised from IPP
IPP reacts with cation generated from DPP to form GPP
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