Summary
Summary CIPT minor week 7
- Module
- Institution
Summary of 3 pages for the course Minor Cancer-Immunity-Personalized therapies at VU (CIPT minor week 7)
[Show more]
Seller
Follow
nooralkemade
Reviews received
Content preview
Week 7: Personalised medicine IPrinciples in laboratory diagnostics
Step 1: Biomarker identification
● Done via genomics, proteomics, metabolomics, lipidomics, and glycomics.
Step 2: Test development
● What is a good test? → should be easy, cheap, easy sample collection
● Validation of a laboratory test: precision and trueness = accuracy
○ Precision: how close is the observed
sample to the mean of samples? = random
error
○ Trueness: how close is the observed
sample to the real sample value? =
systematic error.
■ Reference to measure should be
available,
■ Clear what is analysed.
■ reference material should be
identical to the analyst in patients.
Step 3: Clinical validation
● Confidence interval: reference interval of “normal”.
Determined by:
○ Selection bias for reference interval: within and between subject variation.
○ Preanalytical consideration analytical considerations
● Sensitivity = true positives in an ill population
● Specificity = true negatives in a healthy population
disease
yes no
test result = positive true positive (A) false positive (B)
negative false negative (C) true negative (D)
how to calculate? sensitivity = A/A+C specificity = D/B+D
● ROC curves = sensitivity vs
1-specificity for different cut-off
values.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller nooralkemade. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £5.59. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
76710 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now