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Chemotherapy Biotherapy Certification/95 Complete Questions and Answers
Chemotherapy Biotherapy Certification/95 Complete Questions and Answers
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Chemotherapy BiotherapyCertification/95 Complete Questions and
Answers
Resources - -nccn.org
cancer.org
-LESSON 1: Cell cycle - -g1- increase in size
s- dna replicated
g2- cell enlarge and ready to divide
m phase- 2 hours
-mitosis - -4 stages, prophase, metaphase, anaphase, telophase
-chemo targets certain points in the process
-apoptosis - -programmed cell death
-hematopoiesis - -formation of blood cells & how cells differentiate
-myeloid: pre cells mature into RBCs, platelets and WBCs
-lymphoid: pre cells- mature into WBCS
-Principles of Biotherapy: p51-95 immunology - --defense against foreign
organisms, homeostasis (destroy aged cells), surveillance
-immune responses - -innate: primary line of defense, non specific, no
memory
adaptive: secondary line of defence with specific memry
-cytokines - --effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing
comunication between cells of the immune system
-regular antiboddy production and function of b cells
-vaccines for cancer prevention - --hep B prevents hepatitis and
hepatocellular carcinoma
-hpv vaccine
-filgrastim aka neupogen - -SC or IV to derease infection in patients with
neutropenic fever associated with myelosuppressive anticancer treatments
for nonmyeloid malignancies
-tbo-filgramstim/ pegfilgrastim - -reduce duration of neutroenia in patients
with non myeloid malignancies
, -palifermin - -IV to dec incidence of oral mucositis in patients with hem
malignanies before BMT
-sargramostim - -aka leukine - patients with AML following chemo to shorten
neutrophil recovery and reduce incidence of infection
-IFN gamma - -reduce frequency and severity o infections related to
granulomatous disease
-aldeleukin - -treat renal cell carcinoma and metastatic melanoma
-oprevelkin - -prevent severe thrombocytopenia and refuce need for
platelet transfusions in patients with nonmyeloid malig
-plerixafor - -with filgrastim to mobilize hematopoeitc stem cells for
collection from peripheral blood of patients
-sipuleucel - -castrate resistant prostate cancer
-rituximab - -rituxan- treatment of relapsed or refractory low grade follicular
b cell NHL_ first line traetment in combo with chemo in patients with
response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema, hypoxia,
rigors, dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
-slow infusion to resolve some side effects, side effects reduce with each
infusion
-immune system - -1st line: skin , ucous membrane, gut flora
second line: phagocytes:
3rd line antibodies, t and b cells
-malignant tumor (cancer) - -cell strcuture different from parent tissue, cell
division uncontrolled, loosely adherent, invade neighboring tissue, establish
blood vessels
-Approaches to treatment - -cure: prolonged absence of disease
control: no further growth
and palliation : comfort
-neoadjuvant - -therapy in the first step to shrink a tumor before the main
treatment) surgery is given
-chemo, radiation, hormone therapy
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