Fundamentals of Chemotherapy
Immunotherapy Administration
Hematologic cancer (blood cancer) - --cancer that begins in bone marrow or
immune system cells.
-Ex: leukemia, lymphoma, multiple myeloma
-Leukemia - -cancer starts in blood-forming tissues like bone marrow
-causes lots of abnormal blood cells to be produced and enter bloodstream
-Lymphoma - --cancer that begins in immune system (WBC=lymphocytes)
-hodgkin and non-hodgkins
-B lymphocytes (B cells) - make antibodies (bacteria and viruses, most
common lymphoma
-T lymphocytes (T cells) - boost/slow immune, destroy germs and abnormal
cells
-Hodgkin lymphoma - -Reed-Sternberg cell (cancer cells in classic)
-typically starts in B cells
-Non-Hodgkin's Lymphoma - --large, diverse group of cancers in immune
system cells
-indolent (slow growing) or aggressive (fast)
-Myeloma - -Cancer in plasma cells (WBC that produce antibodies)
-Chemotherapy - -All antineoplastic agents used to treat cancer, given
through oral and parenteral routes or other routes as specified in the
standard, not including hormonal therapies.
-Who can order chemotherapy? - -Written and signed by licensed
independent practitioners (MD/DO, PA, Oncology NP)
-Can you use verbal orders for chemotherapy? - -NO! Only when
holding/stopping admin.
-Who can administer chemotherapy? - -Registered Nurses with specialized
education, prep and training. See specific state laws and statutes
-How often is chemo competency reassessed> - -Annual continuing ed and
competency assessment is recommended
, -What is the dose verification process? - --confirm plan with patient
-two practitioners verify: drug name, dose, volume, rate, route, expiration
date, appearance
-document verification in chart
-What PPE is required for IV Chemotherapy? - --Gloves: two pairs, HD tested
-Gown: disposable, back closed, long sleeved
-Respirator: NIOSH approved
-Eye & Face: face shield/mask
-Neoadjuvant therapy (tumor burden) - -Chemo BEFORE primary treatment
(common in breast and colon)
-Adjuvant therapy - -Chemo AFTER primary treatment (common in solid
tumor)
-Bone Marrow - -soft, sponge-like tissue in center of most bones, produce
WBC, RBC, and platelets.
-Myelosuppression - -bone marrow activity is decreased, causing less RBC,
WBC and Platelets.
-Myeloablation - -severe myelosuppression
-Induction phase - -initial phase, typically in hospital, intended
myelosuppression
-Consolidation phase (intensification/postremission therapy) - -after
successful induction, kills cancer cells left in body (ex radiation, stem cell
transplant)
-Synergy - -when one chemo drug helps another work better at the same
time
-Complete response - -no identifiable cancer present for at least one month
or longer
-Partial response - -Measurable tumor reduced by 50% for at least one
month with no new tumors
-Stable disease - -Tumor size reduced by less than 50% or less than 25%
increase in growth
-Progressive disease - -tumor growth more than 25% or new cancer
-What are the phases of the cell cycle? - --G1 phase
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