1) Introduction to Enzyme Control Mechanisms
a) prevent wasteful end product
b) Controlled by rate-limiting reactions
i) Key regulatory enzymes catalyze these rate-limiting reactions
(1) non-equilibriu
(2) irreversible
(3) controlled by a variety of factors other than substrate availability
c) allow cells to respond to changing environmental conditions
d) vary in duration of metabolic change, some are very fast while others are have
longer durations
e) Variety of mechanisms in which enzyme activity may be controlled
i) feedback inhibition
ii) feedforward activation
iii) reversible covalent modification
iv) Calcium Binding Proteins
v) Proteolytic activation; limited proteolysis
vi) allosteric control
vii) induction and repression
viii) substrate availability
ix) compartmentation.
2) Time Frame
a) Long time frame
i) Altering the amount of an enzyme within a cell by:
(1) influencing the rate of protein synthesis
(2) influencing rate of protein
ii) hours or days
b) Medium time frames
i) several minutes to seconds
ii) covalent modification of enzyme structure by reversible phosphorylation
(1) most common mechanism employed in eukaryotes at serine and threonine
residues
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller rsartorius. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £2.99. You're not tied to anything after your purchase.