Lecture notes
ANS Principle of drug action
- Module
- 4py009 (4PY009)
- Institution
- University Of Wolverhampton
ANS Principle of drug action
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Principles of Drug Action – 4PY009 – Detailed lecture notesAutonomic Nervous system (ANS), Part 2 (week 3)
More on Neurones
All somatic motor neurons release the neurotransmitter ACh
in neuromuscular junctions, which binds to and stimulates
nicotinic receptors. If the level of stimulation reaches
threshold, this has an excitatory effect and skeletal muscle
fibres contract.
Preganglionic fibres for both parasympathetic and
sympathetic nervous systems also release ACh that binds to
nicotinic receptors.
All parasympathetic postganglionic fibres release ACh, but
here muscarinic receptors are stimulated.
Most sympathetic postganglionic fibres release
noradrenaline (NA), which binds to adrenergic receptors.
Sympathetic postganglionic fibres that innervate sweat
glands release ACh, which binds to muscarinic receptors.
In 1910 Dale suggested that noradrenaline mimicked
sympathetic nerve stimulation more closely than adrenaline.
Dale (1914) discovered that ACh has two types of activity.
Muscarinic actions of ACh can be reproduced by muscarine,
which is can be extracted from Amanita muscaria/fly agaric.
These effects can be blocked using atropine (extracted from
Atropa belladonna/deadly nightshade), to leave ACh’s
nicotinic effects, which can be reproduced using nicotine
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