Exam (elaborations)
UNE BIOCHEMISTRY WEEK 6 EVAL QUESTIONS AND ANSWERS.
- Institution
- Oxford University (OX)
UNE BIOCHEMISTRY WEEK 6 EVAL QUESTIONS AND ANSWERS.
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UNE BIOCHEMISTRY WEEK 6 EVALQUESTIONS AND ANSWERS
Enhanced transcription of regulatory enzymes
Cortisol enhances gluconeogenesis through an increase in transcription of enzymes such as
PEPCK and those enzymes needed for protein catabolism. - answer When cortisol binds to its
receptor, which of the following events occur to stimulate gluconeogenesis?
Hepatic glycogenolysis
During an overnight fast, hepatic glycogenolysis would be the predominant supplier of blood
glucose. As the period of fasting persisted, maintenance of blood glucose would transition to a
greater reliance on gluconeogenesis. - answer During an overnight fast, which of the following is
the major source of blood glucose?
Increased biotin, increased Acetyl CoA, decreased Oxaloacetate, decreased Malate
Pyruvate carboxylase requires both biotin and acetyl-CoA for activation. - answer Which of the
following combinations of compounds is required to fully activate pyruvate carboxylase (+
indicates compound is necessary; - indicates compound is not necessary)?
CO2 is required
For pyruvate to be used in the synthesis of PEP, it must first enter the mitochondria and be
come carboxylated by pyruvate carboxylase. This process requires CO2. This is a carboxylation
reaction that requires both acetyl-CoA(as an allosteric activator) and biotin. From there, the
synthesized oxaloacetate can be reduced to malate and shuttled out of the mitochondria. -
answer Which of the following events occurs during the formation of phosphoenolpyruvate
from pyruvate during gluconeogenesis?
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