Exam (elaborations)
BMTCN CH.03 WITH 100% CORRECT ANSWERS
- Institution
- Oxford University (OX)
BMTCN CH.03 WITH 100% CORRECT ANSWERS
[Show more]
Content preview
BMTCN - CHAPTER 5 (INTRO ANDACUTE GVHD) QUESTIONS AND
ANSWERS
What is graft vs host disease? - answer Donor T cells recognize antigens on cells in the recipients
organs as foreign and mount an immunologic repsonse
What are the two categories of GVHD? What determines the category? - answer Acute and
chronic. Clinical manifestations categorize GVHD
What does acute GVHD present as? - answer Erythematous, maculopapular rash, nausea,
vomiting, anorexia diarrhea, ileus, liver disease that occurs within 100 days after transplant, DLI
What is presistent, recurrent, or late onset acute GVHD present as? - answer Features of acute
GVHD AND occurs beyond 100 days post-transplant OR DLI
When does acute GVHD often occur? - answer During taper or withdrawal of
immunosuppressants
What are the manifestations of chronic GVHD? - answer Autoimmune diseases and NO
characteristic of acute GVHD, involves multiple organs (GI, eyes, skin, oral, lung,, liver)
When are most cases of chronic GVHD diagnosed? - answer Within the first year post transplant
What is overlap syndrome in GVHD? - answer When features of both chronic and acute appear
together
What is hyperacute GVHD? - answer Severe form of acute GVHD
, What are the symptoms of hyperacute GVHD? - answer -fever
-rash before engraftment
-hepatic dysfunction
-development of greenish diarrhea with more than 5 stools per day
What is the treatment for hyperacute GVHD? - answer high dose steroids
What are the risk factors for the development of GVHD? - answer -degree fo HLA mismatch
-PBSC as graft source
-Sex mismatch: greater risk with previously childbearing female donor TO a male recipient
-donors older than 40 yr
-hgih doses of TBI
-conditioing intensity (myeloablative)
-higher CD34 cell dose
-GVHD prophylaxis
-unmaipulated graft (not depleted T cells)
-donor transfusion status
-related vs unrelated (more severe GVHD occurs with HLA mismatched or unrelated donors
compared with HLA matched siblings
What are the requirements of GVHD? - answer 1. graft must contain immunocompetent cells
2. histoincompatibility must exist between donor and recipient.
3. recipient must be incapable of mounting an effective immunologic reaction against the graft
Describe the first phase of the patho of GVHD - answer Pre-transplant damage to host tissues =
mucosa is more permeable = large amounts of cytokines (TNF and IL1) = cytokines upregulate
major and minor histocompatibility complexes on host tissue = makes it easy for donor T cells to
recognize host tissue as foreign and mount inflammatory response
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller FREEMANSHARP. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £10.04. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
73314 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now