Exam (elaborations)
BMTCN NUMBERS TO KNOW
- Institution
- Oxford University (OX)
BMTCN NUMBERS TO KNOW
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FOUNDATIONS OF TRANSPLANT EXAMQUESTIONS AND ANSWERS
CXCR4 - answer Regulates trafficking and homing of stem cells
Expressed on surface of HSCs
1st stem cell transplant - answer 1960's, infant with immunodeficiency disorder, matched sib
SDF-1 - answer Secreted by bone marrow stromal cells
Involved in retaining HSCs within bone marrow as well as releasing HSCs into circulation
Stem cell retention in bone marrow - answer Involves SDF-1 gradient, cellular adhesion
molecules (CAMs), and binding action of CXCR4
Myeloid progenitor cells differentiate into... - answer - RBCs
- Megakaryocyte (platelets)
- Neutrophils
- Basophils
- Eosinophils
- Monocytes/macrophages
- Dendritic cells
- Mast cells
Goals of transplant: non-malignant diseases - answer Cell line replacement
, Goals of transplant: malignant diseases - answer Tumor ablation
Graft vs. Tumor effect - answer - Promoted by withdrawal of immunosuppression
- Promoted by DLI
- Decreases in absence of GVHD
Common hematological malignancies treated with auto HSCT - answer - Hodgkin disease
- Non-Hodgkin lymphoma
- Multiple myeloma
Common hematological malignancies treated with allo HSCT - answer - ALL
- AML
- CML
- MDS
- NHL
- Juvenile myelomonocytic leukemia
Solid tumors treated with auto HSCT - answer - Neuroblastoma
- Sarcoma
- Germ cell tumors
- Brain tumors
- Ovarian cancer
- Melanoma
- Lung cancer
Common non-malignant hematologic diseases treated with allo HSCT - answer - Severe aplastic
anemia
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