Exam (elaborations)
BMTCN REVIEW QUESTIONS WITH 100% CORRECT ANSWERS 2023
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- Oxford University (OX)
BMTCN REVIEW QUESTIONS WITH 100% CORRECT ANSWERS 2023
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BMTCN TEST QUESTIONS WITHVERIFIED CORRECT ANSWERS
What type of transplants commonly have PTLD as a secondary malignancy? - answer Allo HSCT
with T-cell depleted graft
Therapies associated with therapy-related acute leukemia and MDS - answer alkylating agents
(eg. Cytoxan, cisplatin, melphalan, busulfan, ifos) , radiation, topoisomerase II inhibitors (eg.
doxorubicin, etoposide, mitoxantrone)
Genetic predispositions that increase risk of primary and secondary cancers - answer
neurofibromatosis type 1, Fanconi anemia
Risk factors for PTLD - answer T-cell depleted graft, mismatched related or unrelated donor.
Busulfan, ATG, mAbs, TBI
patient w/ primary immunodeficiency, acute or extensive GVHD, EBV
Risk factors for secondary solid tumors - answer younger age at HSCT, TBI, chronic GVHD,
increasing time from transplant, infections, genetic predisposition, lifestyle factors
Treatment options for PTLD - answer EBV-specific cytotoxic T cells, mAbs targeted to B cells
(rituximab), combination chemotherapy
Treatment options for secondary MDS/acute leukemia - answer conventional chemo or allo
transplant. Poor outcomes.
QOL domains - answer Physical, Functional, Psychological, Social, Spiritual/existential, Multiple
interactions between domains
, Altered sexual health in male HSCT survivors - answer damage to the hypothalamic-pituitary-
gonadal axis: elevated FSH, elevated LH, low testosterone levels; cavernosal arterial insufficiency
causing ED
Altered sexual health in female HSCT survivors - answer alkylating agents and radiation cause
infertility and premature ovarian failure, elevated FSH and LG, low estradiol, menopausal
symptoms
Risk factors for vaginal alterations post transplant - answer POF (premature ovarian failure), TBI,
chronic GVHD
Risk factors for infertility - answer pre-HSCT antineoplastic therapy, exposure to alkylating
agents, TBI or pelvic irradiation, older age
Pregnancy risks in HSCT survivors - answer increased risk of preterm birth and low birth weight,
cardiac decompensation during pregnancy 2/2 prior anthracycline exposure. Similar rate of
spontaneous abortion to general population.
Recommended vaccines - answer Pneumococcal, Diptheria-tetanus, Pertussis, Meningococcal,
Inactivated polio
Hep B, Recombinant Hep A, Influenza, Measles Mumps and Rubells, HPV
When can HSCT survivors get vaccines? - answer inactive vaccines start at 6 months post HSCT,
live vaccines start at 2 years post HSCT (in absence of ongoing immunosuppression and GVHD)
Most common secondary malignancy in pediatric patients who received radiatios? - answer
Nonsquamous call carcinoma
Interventions/treatment for vaginal chronic GVHD - answer topical steroids, topical
cyclosporine, vaginal dilation
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