100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
BMTCN Review Chapter 5 - Graft-Versus-Host Disease 2023/2024 already passed £15.46   Add to cart
Quickly navigate to
Preview
  2.  
  3. BMTCN
  4.  
  5. BMTCN

Exam (elaborations)

BMTCN Review Chapter 5 - Graft-Versus-Host Disease 2023/2024 already passed
 3 views  0 purchase
  • Module
  • BMTCN
  • Institution
  • BMTCN

BMTCN Review Chapter 5 - Graft-Versus-Host Disease GVHD - correct answer Competent donor t-cells recognize antigens, mount immune response, and and attack recipient organs Classifications of GHVD - correct answer Acute Chronic Hyperacute Overlap Syndrome Acute GVHD - correct answer ...

[Show more]

Preview 3 out of 28  pages

Document information

  • November 23, 2023
  • 28
  • 2023/2024
  • Exam (elaborations)
  • Questions & answers

Subjects

  • bmtcn review chapter 5 graft versus host disease

Written for

  • BMTCN
  • BMTCN

Seller

avatar-seller
Sakayobako30

Reviews received

Content preview

BMTCN Review Chapter 5 - Graft-Versus-
Host Disease
GVHD - correct answer Competent donor t-cells recognize antigens, mount immune response, and and attack recipient organs
Classifications of GHVD - correct answer Acute
Chronic
Hyperacute
Overlap Syndrome
Acute GVHD - correct answer Generally occurs within first 100 days or nor meeting chronic criteria
Presents as erythematous, maculopapular rash, nausea, vomiting, anorexia, profuse diarrhea, ileus, or cholestatic liver
Chronic GVHD - correct answer Has manifestations of autoimmune disease and no charaacteristics of acute GVHD
Involves multiple organs (skin, eyes, oral mucosa, ling, GI tract, liver)
Usually diagnosed within the first year
Median onset 4-6 months MOST FREQUENT OCCURRENCE IN FIRST YEAR
Hyperacute GHVD - correct answer Can be fatal
Fever greater than 38.3 C on two occasions or for more than 3 days prior to engraftment with lack of resolution after minimum of 3 days with abx and antifungal agents
rapid development of rash
Hepatic dysfuntion
More than 5 stools per day of mucoid green diarrhea
High dose steroid treatment
Difficult to differentiate with engraftment syndrome
Overlap Syndrome - correct answer Features of acute and chronic appear at the same time
Incidence of GVHD - correct answer Grades 2-4, 20-85%
Risk factors (Acute and Chronic) - correct answer Most important: degree of HLA mismatch
Graft source
Gender mismatch (greatest: parous female donor to male recipient)
Donors over age 40 High dose TBI
Conditioning intensity
Higher CD34+ cell count
Prophylaxis
Unmanipulated graft (t-cell depletion)
Donor transfusion status
Related vs unrelated (best: HLA mathced sibling)
Pathophysiology Phase 1 - correct answer Occurs prior to transplant when preparative regimen may damage host (GI, skin, liver)
Permeable mucosa leads to secretion of inflammatory cytokines
Cytokines upregulate major histocompatibility complexes and minor histocompatibility antigens (host)
Mature T cells (donor) recognize upregulated recipient tissue as foreign and mount an immunologic response
Pathophysiology Phase 2 - correct answer Donor T cell activation
Donor T cells come into contact with minor antigens on recipients cells blood stream
Some donor T cells recognize antigens as foreign and bind them

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller Sakayobako30. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for £15.46. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

73314 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now

Start selling
£15.46
  • (0)
  Add to cart