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tubular structure and function lecture

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includes: bicarbonate reabsorption, proximal convoluted tubule, hormonal regulation, glucose reabsorption, potassium, osmosis,regulation of water output, influence of other hormones

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  • December 21, 2023
  • 3
  • 2021/2022
  • Lecture notes
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1
Week 6, Lecture
Tubular Structure and Function
Bicarbonate reabsorption
 Descending filtrate
o Hydrogen ions come out to cells or go to filtrate
o Carbonic acid made into CO2 and bicarbonate
o Carbonic anhydrase
o NBC1 into blood
 Sodium
 Bicarbonate
 Ascending
o Chloride ions go in
o Bicarbonate moved out
Proximal convoluted tubule
 Sodium reabsorption
 Filtrate coming down
 Glucose channel
 Sodium goes with glucose into the cell
 Moves to blood
 3 Sodium goes out and 2 potassium comes in
 2nd active transport
 65% of sodium reabsorbed regardless of hormonal control
 Remaining sodium is reabsorbed again
 Never secreted in the other direction
 Osmosis
Hormonal regulation of sodium and water output
 Renin angiotensin aldosterone reflex cycle
 Aids sodium reabsorption
 Also absorbs water
 Water retention
 Blood pressure corrected
Removing sodium and water from blood
 ANP
o Atrial natriuretic peptide
o Overstretched atria
 BNP
o B-type natriuretic peptide
o Overworked ventricles
 Dilate afferent arterioles
o Increases blood flow and filtration
o Suppresses sodium reabsorption and water retention
Proximal Convoluted Tubule glucose reabsorption
 180g of glucose a day from plasma
 All reabsorbed in a healthy person
 Body efficient in the use of resources
 Reabsorption increases with glucose increase
 After glucose max absorption is reached glucose is secreted and found in urine
 Glycosuria

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