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UNE Biochemistry Midterm Review – Q’s And A’s (A+)
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UNE Biochemistry Midterm Review – Q’s And A’s (A+)
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UNE Biochemistry Midterm Review – Q’s And A’s (A+)Under low energy conditions, AMP will bind to phosphofructokinase I and
glycogen phosphorylase at site unique to the active site. This enhances the
activity of these enzymes. This is an example of which of the follow types of
enzyme regulation? Correct Ans - Allosteric activation
An example of enzyme activation by cleavage is best illustrated by which of
the following? Correct Ans - Activation of chymotrypsinogen to
chymotrypsin
Children with cystinosis have growth delay and both renal and ocular
issues due to accumulation of cysteine in cellular lysosomes. The defect
involves a specific lysosomal membrane receptor that facilitates cysteine
removal from the cell. An effective therapy has been administration of a
drug with a similar structure to cysteine. This therapy reflects the general
principle that competitive inhibitors typically resemble the structure of
which of the following? Correct Ans - Substrates or ligands that
bind the active site
The association of DNA and histones can be modified by histone
acetylation. A decrease in histone acetylation will have which of the
following impacts on the association of DNA and histones? Correct Ans
- Increase DNA: histone association
A 28-year-old male is recently diagnosed with HIV. As part of his treatment
he is prescribed Nevirapine which interferes with retroviral reverse
transcriptase enzyme. Using the graph below, which of the following best
describes the impact of this drug on its target? Correct Ans - It
reduces the catalytic activity of the enzyme
Which of the following is an example of enzyme regulation through
covalent modification? Correct Ans - Phosphorylation of muscle
glycogen phosphorylase
Use the figure below to compare the activities of glucokinase and
hexokinase. Based on this information, which of the following is a true
statement? Correct Ans - Glucokinase has a higher Km than
hexokinase.
, A new enzyme is discovered that increases in activity when it is
phosphorylated on an exposed tyrosine residue. Phosphorylation of this
amino acid is classified as which of the following? Correct Ans -
Covalent modification
An enzyme is participating in a general acid-base catalysis reaction with an
optimal reaction pH of 6.0. If acid is added to the environment reducing the
pH to 3, what is the likely impact to the rate of reaction? Correct Ans -
The rate of the reaction is likely to decrease as the pH is out of optimal
catalytic range
If a mutation is made within the active site of an enzyme resulting in a
decrease in Km, which of the following will be true with respect to the
enzyme kinetics? Correct Ans - The enzyme will require a lower
substrate concentration to reach ½Vmax
In the malate aspartate shuttle, glutamate is converted to _________ in the
mitochondria while aspartate is converted to ___________ in the cytosol.
Correct Ans - α-ketoglutarate; oxaloacetate
ATP is a high energy molecule that is often hydrolyzed during reactions.
The energy within ATP is stored primarily in which of the following
components of the molecule? Correct Ans - In the high energy
phosphate bonds
Which of the following would be consistent with an exergonic reaction?
Correct Ans - ΔG0 would be negative
The malate-aspartate shuttle is used to move reducing equivalents of
cytosolic NADH into the mitochondria where it can be oxidized. Which of
the following compounds is used to move the reducing equivalents from
cytosolic NADH into the mitochondria? Correct Ans - Malate
Succinate is a substrate for which complex in the electron transport chain?
Correct Ans - Complex II (Succinate-Q reductase)
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