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UNE Medical Biochemistry Midterm Review – Q&A
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UNE Medical Biochemistry Midterm Review – Q&A
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UNE Medical Biochemistry Midterm Review – Q&ARibose and NADPH Correct Ans - A family presents for genetic
counseling. The couple has two female children who are alive and well;
however, their infant son recently died in the nursery with severe
hemolysis (lysis of red blood cells) and jaundice. The wife recalls she lost a
brother in infancy with severe hemolysis, induced after a viral infection.
The physician suspects a glucose-6-phosphate dehydrogenase deficiency,
this would result in a deficiency in which of the following compounds in
red blood cells?
Transketolase Correct Ans - A patient presents to the emergency
department with lactic acidosis. A deficiency in thiamine (TPP) is
suspected and this will be consistent with a decrease in the activity of
following enzymes?
UDP-Glucose Correct Ans - Galactose 1-phosphate is initially
converted to glucose 1-phosphate and requires which of the following
compounds?
Thiamine diphosphate Correct Ans - Which of the following
cofactors is required for transketolase activity?
Glyceraldehyde 3-phosphate Correct Ans - Aldolase B facilities a
reaction that cleaves fructose 1-phosphate into two 3-carbon molecules
that will enter glycolysis as which of the following compounds?
Glycolysis Correct Ans - High levels of activity of the non-oxidative
portion of the pentose phosphate pathway will directly produce
intermediates of which of the following pathways?
Glucose 6-phosphate dehydrogenase Correct Ans - The major
regulatory step of the pentose phosphate pathway is catalyzed by which
enzyme?
VLDL particles Correct Ans - Insulin stimulates fatty acid synthesis
in the liver. These fatty acids are transported to the adipose tissue as which
of the following?
, Free fatty acids Correct Ans - A young woman goes to work without
eating breakfast and skips lunch. In this scenario, which of the following
pathways is providing substrates used to generate ATP in the liver?
Glucagon Correct Ans - Caffeine is a natural inhibitor of
phosphodiesterase. If you were to consume a large amount of coffee you
would likely see a prolonged response to which of the following stimulants
or hormones?
They enhance transcription when bound to receptors Correct Ans -
A teenage female presenting with lack of menstruation (amenorrhea) is
found to have a dysfunctional steroid receptor characteristic of androgen
insensitivity syndrome. Which of the following statements accurately
describes steroid hormones?
Intracellular receptors Correct Ans - Steroid hormones bind which
of the following types of receptors?
They are specific to a chemical messenger Correct Ans - Which of
the following is a characteristic of all receptors?
Free fatty acids Correct Ans - What is the primary oxidized fuel for
skeletal muscle in the fasted state?
Cyclic-AMP response element binding protein (CREB) Correct Ans -
cAMP elicits multiple cellular responses. The effects of cAMP on gene
transcription are directly mediated by which of the following DNA binding
proteins?
GLUT4 Correct Ans - An individual is recently diagnosed with Type
2 diabetes. In this individual, hyperglycemia may in part be due to
inactivity of which of the following glucose transporters on skeletal
muscle?
Adenylyl cyclase Correct Ans - Glycogen degradation in the liver
can be enhanced by elevated glucagon and the activation of a G αs receptor.
The initial step in this cascade involves which of the following second
messengers or active enzymes?
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