Summary
Summary YR 2 CONTENT
- Institution
- University Of Sunderland (UoS)
Summary of 3 pages for the course Foundations Of Biomedical, Behavioural And Social Sciences For Medicine 2020/21 at UoS (YR 2 CONTENT)
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NeoplasiaNeoplasia: Autonomous/independent growth of abnormal tissue, the growth continues
regardless of the stimulus has been removed
Growth is more rapid
Invade surrounding tissues
Metastasise
Kill host in which it originates
Normal growth is regulated
Cell division=cell death
Tumour stage important: in diagnosis and treatment options
Carcinoma in situ- confined to the epithelium- hasn’t spread to local tissue
Invasive
Metastatic
Dysplasia:
disordered growth of the epithelium- confined to the epithelium
Reversible
Nuclei darker
When all the epithelium is dysplastic- no normal cells=neoplasia
Carcinoma in situ=basement membrane
intact, abnormal growth confined to the
epithelium
Invasive carcinoma- neoplastic cells
invade the BM
Benign vs malignant-important for
pathological decision
Properties:
Anaplastic-poorly defined cells-
lack of differentiation
Pleomorphic
Hyperchromatic nuclei
1:1 nuclear to cytoplasmic ratio
Hallmark of neoplasia: Angiogenesis:
Growth of new blood vessels from the host vasculature
Normal tissues=growth in a confined compartment
Metastasis: spreading of a tumour to distant sites in the body
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