Lecture notes
Lecture notes BHCS2004 - Cell Biology (BHCS2004)
- Institution
- Plymouth University (UOP)
Lecture notes BHCS2004 - Cell Biology (BHCS2004)
[Show more]
Seller
Follow
Content preview
BHCS2004 introduction to cell signaling.LO: understand core principles to cell signaling
Name cell functions:
• Metabolism
• Communication
• Transport
• Motility
• Defense
Give three basic concepts of cell communication.
-cells should sense and respond to environments
-must:
+ Sense stimuli.
+ Integrate diverse inputs.
+ Produce important biological responses.
-communicate with other cells to enable correct cellular, tissue and organ function
Name the disruption of cell signaling and altered response which causes altered health:
• Proliferation
• Differentiation
• Apoptosis
Describe different. Response rates:
+ Fast = electrical, ion mediated
+ Medium = enzyme activity
+ Slow = gene expression
Principle 1: Cells respond to multiple signals.
To survive: trophic factors and death signals
Divide: mitogenic factors
, Differentiate: growth, trophic, factors and morphogens
Biological Responses:
• Proliferation= mitosis. Mitogens (cyclins, CDKs, Rb, E2F, wee, cak, MPF, APF, cdc25 etc.)
• Differentiation: specific change in protein expression or activity leading to alteration of
function ‘maturation’ (receptors, cytokines, CAM, cytoskeleton, channels, signal
transduction components etc.).
• Life span: apoptosis, autophagy (FasL, death receptors, AKT, p53, caspases, mdm2,
surviving.)
Principle 2: Signalling involves energy conversion.
Cells in mature organism must respond to signals to survive, adapt and be
successful in their environment
Signals come from external environments:
Ex of physical/chemical external signals:
Light
Sound these are converted to nerve signals (elec), chemical signals (ATP/GTP)
Touch
Odorant chemicals
Principle 3: same signalling molecule can induce different responses in different target cells
Internal signals:
Hormones:
Insulin
Testosterone
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller 248748hguhhtyry. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £10.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
66579 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now