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Biopharmaceutics (Violet) – PACOP Exam Questions with 100% Correct Answers {Updated 2024}
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Biopharmaceutics (Violet) – PACOPExam Questions with 100% Correct
Answers {Updated 2024}
It is the ability of a drug to exist in two or more crystalline form:
A. Chirality
B. Polymorphism
C. Stereoisomerism
D. A and C
E. None of these B
Arrange the following dosage forms from highest to lowest dissolution rate:
I. Solution
II. Capsule III. Suspension
IV. Tablet
A. I, II, III, IV
B. I, III, II, IV
C. IV, III, II, I
D. IV, II, III, I
E. None of these B
All of the following statements aretrye regarding particle size of a drug, EXCEPT:
A. Reducing the particle size can decrease the surface are the molecule exposed to the solvent.
B. Reduction of paticle size can be achieved by micronisation using jet mill, spray drying and air attrition methods.
C. The dissolution of some drugs available in the market has been improved by reducing the particle size.
D. Reducing the particle size of a drug may increase drug absorption.
None of these A
Which of the following may increase drug dissolution rate?
I. Too much binder
II. Insoluble diluents
III. High amount of lubricants
A. I only
B. I and II
C. II and III D. I, II, AND III
E. None of these E.
Which of the following is not true regarding the purpose of tablet coating?
A. Improves palatability
B. Improve aesthetic value of tablet
C. Improve stability
D. Improve in-vivo degradation
E. None of these D
A surface active agent that facilitates the absorption of lipophilic drug or water insoluble drugs
A. Bile
B. Albumin
C. Renin
D. Gastric acid
E. None of these A
Phase 2 metabolism that protects the body against chemically reactive metabolites
A. Sulfate conjugation
B. Glutathione conjugation
C. Methylation
D. Acetylation
E. Glycine conjugation B
All of the following listed below are processes of drug excretion, EXCEPT:
A. Glomerular filtration
B. Active secretion
C. Tubular secretion
D. Tubular reabsorption
E. None of these E
It is the basic functional unit of the kidney
A. Glomerulus
B. Loop of henle
C. Nephron
D. Collecting tubule
E. None of these C
Creatinine clearance of a patient with kidney failure
A. 60-89 mL
B. 30-59 mL
C. 15-29 mL
D. <15 mL
None of these D
Which of the following drugs listed below will increase its clearance at alkaline urine?
I. Amphetamine
II. Imipramine
III. Barbiturates
IV. Salicylic acid A. I and II
B. II and III
C. III and IV
D. All of these E. None of these C
Which of the following correctly describes ion trapping
A. Changing the pH of urine used to facilitate the elimination of drug that proved to be toxic to a patient or has been taken in overdosed amount
B. Administration of acidic drug to neutralize am alkaline poison in the stomach
C. Alkalinizing the urine to facilitate excretion of weakly basic drugs
D. A and C
E. None of these A
Discipline that applies Pharmacokinetic concepts and principles in humans in
order to design individualized dosage regimens that optimize the therapeutic
response of a medication while minimizing the chance of an adverse drug reaction
A. Clinical toxicology
B. Clinical pharmacy
C. Clinical Pharmacokinetics
D. Pharmacotherapeutics
E. None of these C
Chemical conversion of the drug molecule, usually by an enzymatically mediated reaction, into another chemical entity referred to as a metabolite
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
None of these C
Volume of serum or blood completely cleared of the drug per unit time
A. Volume of distribution
B. Clearance
C. Elimination
D. Plasma concentration
E. None of these B
Hypothetical volume that relates drug serum concentrations to the amount of drug in the body
A. Volume of distribution
B. Clearance
C. Drug Elimination
D. Plasma concentration
E. None of these A
All of the following factors affects the volume of distribution of drug, EXCEPT
A. Volume of blood
B. Size of various organs and tissue in the body C. Protein binding
D. Physicochemical properties of drug
E. None of these E
The fraction of administered dose that is delivered to the systemic circulation
is known as the
A. Loading of dose
B. Maintenance dose
C. Bioavailability
D. Active dose
E. None of these C
Below is an example of
A. Dose response curve
B. Plasma level time curve
C. Quantal dose response curve
D. A and B
E. None of these B
After the first dose of gentamicin is given to a patient with renal failure the following serum concentrations are obtained
Time after drug administration(h) 1, 24, 48
Concentration (mcg/mL)
7.7, 5.6, 4.0
Compute for the half-life and the elimination rate constant for this patient.
A. 30 hours and 0.0123/hr
B. 45 hours and 0.0146/hr
C. 55 hours and 0.0129/hr
D. 50 hours and 0.0139/hr
E. None of these D
All of the following are true regarding the rate of drug distribution, EXCEPT:
A. The rate of drug distribution will be faster in highly perfuse tissues
B. The blood brain barrier(BBB) prevents the distribution of many polar compounds in the blood to the brain tissues
C. Only the lipophilic compounds can distribute across BBB by passive diffusion
D. The equilibrium between the drug in the blood and the drug in highly perfused tissues is achieved slower than the equilibrium between the drug in
blood and the poorly perfused tissues
E. None of these D
1. Which of the following factors affect drug distribution?
1. Blood perfusion
2. Tissue composition
3. Plasma protein binding
4 Physicochemical properties of drug
A. 1 only
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