Lecture notes
AXON REGENERATION AND PLASTICITY IN THE DAMAGED CNS
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- University College London (UCL)
summary of axon regeneration and myelin formation
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3- AXON REGENERATION AND PLASTICITY IN THEDAMAGED CNS
Sunday, 1 October 2023 14:58
PNS axons - can regenerate after injury
Cajal, 1928 - crashed pns nerves, nerve fibers still continue to grow after the
damage
CNS axons - not able to regenerate (in adults)
Daqing Li - cns axons stopped growing where the injury happened/axons cut back
Bc molecules obstruct them
Spinal cord injury - disconnect commu. Of motor control and sensation
Plasticity: neurons in grey matter can reform
Adjacent neurons can replace the damaged neurons
No regeneration in white matter - contains axons and glial cells
Glial cells:
Astrocytes -- self-defence, forming scar tissue after damage
Microglial - immune cells in CNS, act as microphages after damages
Oligodendricites - reform myelin (one type of myelin) compared to schwann cell,
oligo. can produce myelin 26 times more. 1 Schwann cell produce 1 axon myelin
Inhibitor for stopping axon growth
Failure of axon regeneration in CNS - loss of aligned glial pathways
How to repair? - transplantation of OECs (about olfactory system because the
only area where neurons are continually formed through adult life in CNS)
Newly formed axons accompanied by a type of glia
Open door effect
Astrocytes open the door for OEC to reach the olfactory bulb
OECs injected into the injury area
Rat models
Corticospinal tract lesion
One side being destroyed - rat used one hand
Spinal cord hemi-section
Spinal roots lesion
Optic nerve transection
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