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MCQs G protein coupled receptors
- Module
- Pharmacology
- Institution
- University Of Sunderland (UoS)
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MCQs G-protein coupled receptorm
Q Which of the following statements accurately describes the process of receptor signaling?
A) The formation of a drug-receptor complex leads to a decrease in intracellular biochemical
processes.
B) Upon binding of an agonist drug to its receptor, the receptor undergoes no conformational
changes.
C) Signal transduction involves a chain of biochemical processes triggered by the
conformational change of the drug-receptor complex.
D) Signal transduction is a term used to describe the direct interaction between a drug and
its receptor without any subsequent effects.
② Which of the following represents the correct sequence of stages in the receptor
signaling process?
A) Signal transduction, signal reception, cellular response
B) Cellular response, signal transduction, signal reception
C) Signal reception, signal transduction, cellular response
D) Cellular response, signal reception, signal transduction
③ Which of the following represents a major signal transduction pathway involving
ligand-gated receptors?
A) Activation of second messenger pathways via G-protein-coupled receptors
B) Activation of enzyme-linked receptors
C) Activation of receptor-ion channels
D) Direct activation of gene transcription via intracellular receptors
④ Which signal transduction pathway involves the activation of second messenger
pathways via G-protein-coupled receptors?
A) Activation of enzyme-linked receptors
B) Direct activation of gene transcription via intracellular receptors
C) Activation of receptor-ion channels
D) Activation of second messenger pathways via G-protein-coupled receptors⸻
④ Which major signal transduction pathway is associated with the activation of
enzyme-linked receptors, such as tyrosine kinase-linked receptors?
A) Activation of receptor-ion channels
B) Activation of second messenger pathways via G-protein-coupled receptors
C) Activation of enzyme-linked receptors
D) Direct activation of gene transcription via intracellular receptors
⑥ Which signal transduction pathway directly activates gene transcription via
intracellular receptors?
A) Activation of receptor-ion channels
B) Activation of second messenger pathways via G-protein-coupled receptors
C) Activation of enzyme-linked receptors
D) Direct activation of gene transcription via intracellular receptors
, ⑦ Which of the following accurately describes G-protein-coupled receptors (GPCRs)?
A) GPCRs are exclusively found in the cytoplasm of cells.
B) GPCRs are a small and uniform family of integral membrane proteins.
C) GPCRs convert intracellular signals into extracellular responses.
D) GPCRs constitute the largest receptor superfamily in humans and transduce a wide array
of extracellular signals.
④ What is the primary function of G-protein-coupled receptors (GPCRs)?
A) To regulate cell division
B) To maintain cell structure
C) To transduce extracellular signals into intracellular responses
D) To transport ions across the cell membrane
④ Which of the following statements is true regarding the role of G-protein-coupled receptors
(GPCRs) in human physiology?
A) GPCRs primarily regulate only hormonal responses.
B) GPCRs mediate responses to visual stimuli but not olfactory or taste signals.
C) GPCRs are involved in regulating a wide range of physiological processes, including
responses to hormones, neurotransmitters, and growth factors, as well as vision, olfaction,
and taste signals.
D) GPCRs are not significant targets for pharmaceutical drugs.
⑳ What percentage of drugs currently on the pharmaceutical market target G-protein-coupled
receptors (GPCRs)?
A) Approximately 10%
B) Approximately 25%
C) Approximately 40%
D) Approximately 60%
④ What is the common structural motif shared by all G-protein-coupled receptors (GPCRs)?
A) Six transmembrane alpha-helices
B) Eight transmembrane alpha-helices
C) Seven transmembrane alpha-helices
D) Five transmembrane alpha-helices
⑭ What happens upon agonist binding to G-protein-coupled receptors (GPCRs)?
A) Activation of intracellular enzymes
B) Inhibition of cytoplasmic G-proteins
C) Modulation of downstream effector proteins leading to a biological response
D) Breakdown of the receptor structureIn addition to activating cytoplasmic heterotrimeric
G-proteins,
⑬ what other proteins can G-protein-coupled receptors (GPCRs) couple to?
A) Ribosomes
B) Mitochondria
C) β-arrestins
D) Golgi apparatus
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