GMS 6552 Exam 1 Questions and Answers 100% Accurate!!
Molecular Drug Targets - ANSWER-Receptors-45%
Enzymes-28%
Hormones-11%
Unknown-7%
Ion Channels-5%
DNA-4%
Channel-Linked (Ionotropic) Receptors - ANSWER-Produce cellular effects in milliseconds
Nicotinic ACh receptor
GPCRs - ANSWER-Effects happen in seconds
Muscarinic ACh receptor
Kinase-linked receptors - ANSWER-Effects happen in minutes
Insulin receptor
Receptors linked to gene transcription - ANSWER-Effects happen in hours
Estrogen receptor
Heterotrimeric G proteins - ANSWER-alpha, beta and gamma subunits
GPCR Components - ANSWER-More than 800 receptors
7 transmembrane domains
N and C termini
Conformationally flexible
Constitutively active
GPCR Ligands - ANSWER-Hormones, neurotransmitters, chemokine, ions, amino acids, peptides
G-proteins - ANSWER-a-20
Gas- increases AC
Gai - decreases AC
Gaq - increases PLC
b(6)y(12)
Why use G proteins - ANSWER-Means of amplifying the signal
G proteins can regulate more than one effector PKA - ANSWER-Phosphorylase Kinase (glycogen breakdown)
CREB (gene transcription)
L-type Ca channels (heart contraction)
Pyruvate Kinase (glycolysis)
Hormone Sensitive Lipase (triglyceride breakdown)
Kinase-linked receptor signaling - ANSWER-No second messenger
Protein kinase-linked receptors - ANSWER-Receptors associated with cytosolic kinases
Receptor tyrosine kinases
Receptor serine/threonine kinases
Receptors associated with cytosolic kinases - ANSWER-Ligands:
Prolactin
GH
Interferons
Cytokines
Receptor tyrosine kinases - ANSWER-Receptor tyrosine kinases (RTKs) consist of an extracellular ligand
binding and dimerization domain, a single hydrophobic
transmembrane a-helix and a cytosolic domain with intrinsic
tyrosine kinase activity
Two types of RTKs - ANSWER-Single transmembrane spanning proteins that dimerize when ligand binds (EGF receptor, PGDF receptor)
Covalently linked dimers (insulin receptor, IGF-1 receptor)
PKB/Akt - ANSWER-phosphorylate multiple proteins which regulate a wide variety of intracellular events
Nuclear Receptor Subfamily - ANSWER-Six structural domains:
A/B- AF-1
C- DBD
D- Hinge
E- LBD
F- AF-2
Steroid class receptors - ANSWER-GR, MR, PR, AR, ER
RXR partnered receptors - ANSWER-TR, RAR, VDR, PPAR, a, b, y
Orphan receptors - ANSWER-COUP-TF, HNF-4
Steroid receptor ligands - ANSWER-Steroids
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller papersbyjol. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £9.81. You're not tied to anything after your purchase.
