Lecture notes
Neuronal signalling lecture notes
- Module
- Physiology (BM4MAP)
- Institution
- Aston University, Birmingham (Aston)
in depth notes for Neuronal signalling
[Show more]
Connected book
Book Title:
Author(s):
- Edition:
- ISBN:
- Edition:
Seller
Follow
Content preview
2 types of synapses1. Chemical
- No direct contact between pre and post synapse
- Chemical signal released from axon terminals e.g. acetylcholine
- Acts on dendrites and receptor
2. Electrical
- Known as gap junctions.
- Direct contact between cells
- Allows synchronisation e.g., contraction of heart.
- Found in muscles and neurons.
1. Action potential depolarised end terminals of presynaptic membrane
2. Voltage gated Ca2+ channels open and Ca2+ enter the presynaptic neurone.
3. Causes release of vesicles that contains the neurotransmitters via exocytosis.
4. Neurotransmitter travels across synaptic cleft and binds to receptors on post synaptic
neurone.
5. When the neurotransmitter binds to the sodium channels on post synaptic neurone,
it causes the sodium channels to open and release sodium ions which causes it to
depolarise and action potential can then carry on.
6. An EPSP is when only couple of channels open which isn’t enough as it doesn’t reach
the threshold value.
ü What is a EPSP?
An excitatory post synaptic potential is when a single ion channel is opened which isn’t
enough to reach to the threshold potential to trigger a AP.
ü What is ISPS?
An inhibitory post synaptic potential is when a single ion channel such as Cl- which is
negative therefore making the membrane more negative therefore less likely to trigger an
AP.
Temporal Summation
- Constant firing of EPSP’s to reach the threshold value.
Spatial summation
- Different EPSP’s add up together to reach threshold value.
Presynaptic Inhibition
- Allows extra level of control. A+B cancels out as A is excitatory and B is
inhibitory. D is excitatory so it still fires
and produces a EPSP.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller uneebihsan28. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £10.16. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
52355 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now