ABGC Boards Prenatal Study Set
T21 Risk by Maternal Age - Answer-Age-------------------------------Risk
30 --------------------------------1/952 (.1%)
35 --------------------------------1/385 (.3%)
37 --------------------------------1/227 (.4%)
40 --------------------------------1/106 (.9%)
43 --------------------------------1/50 (3.1%)
Risk of Any Chrom Abnl by Maternal Age - Answer-Age--------------------------------Risk
30---------------------------------1/384 (0.3%)
35---------------------------------1/202 (0.5%)
37---------------------------------1/129 (0.8%)
40---------------------------------1/65 (1.6%)
43---------------------------------1/32 (3.1%)
Maternal Serum Quad Screen - Answer-Measurement of biochemical analytes in
maternal serum to provide adjusted risk for certain conditions.
Performed during second trimester typically 14-21 weeks
SLO vs XL ichthyosis,
SLO has pre and postnatal growth restrictions - Answer-Differentials for extremely
low uE3 on QUAD screen and how can you differentiate
Non-disjunction in Meiosis I - Answer-What is the most common cause of aneuploidy
Factors to take into account for Quad Screen - Answer-Gestational Age: As this
changes so does expected values of each analyte
Weight: as maternal weight increases so does blood volume. Dilutes analytes
Race: Different ethnic backgrounds can affected expected levels
- i.e. African American ancestry tend to have higher AFP levels
, -Diabetic status: insulin dependent diabetics tend to have lower AFP
Effects of inaccurate dating for Quad Screen - Answer--Overestimate (believe
pregnancy is further along) can lead to false positive for Down syndrome.
(Overestimate brings you down)
- Underestimate (reported to be earlier than it is) leads to false positive for NTD.
London (The under is the tubes)
- Generally use first trimester ultrasound for dating rather than LMP
IgM (Most recent)
IgG (It is gone) - Answer-You see IgM but not IgG is this more concerning for recent
infections due to maternal infection.
Memory device
Estriol and hCG low but AFP high early
All low: Late - Answer-Patterns for recent and older fetal demise
Trends of Analytes in Second Trimester - Answer-Analyte Trend
hCG Decreases as GA increases
Inhibin Remains Stable
uE3 Increases with GA
AFP increases with GA
Positive Quad screen pattern Increased risk for Down Syndrome - Answer-HI
(Increased) LO (Decreased)
Pattern of Quad screen with abnormal placental functioning - Answer-AFP: HI
hCG: High
uE3: Low
Inhibin: High
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Gurustudy. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £7.16. You're not tied to anything after your purchase.
