Exam (elaborations)
Chemotherapy_Immunotherapy Certificate Course (ONS,ONCC) Questions and answers
Chemotherapy_Immunotherapy Certificate Course (ONS,ONCC) Questions and answers
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Chemotherapy/Immunotherapy CertificateCourse (ONS,ONCC) Questions and
answers
Alkylating agents - ANSWER-Classification
Break DNA helix strand, thereby interfering with DNA replication
Altretamine (Hexalen) - ANSWER-Alkylating Agent
PO
Ovarian CA
Side effects- nausea, vomiting, skin rash, hypersensitivity reaction, diarrhea
Dose limiting - neuro-toxicity, peripheral neuropathy, myelosuppression
Bendamustine (Treanda/Bendeka) - ANSWER-Alkylating agent
IV
CLL or Indolent NHL
Side effects- pyrexia, nausea, vomiting, skin reactions, TLS, hepatotoxicity, vein
irritation
Dose limiting - myelosuppression
Irritant and vesicant properties
infusion reactions likely to occur in 2nd or subsequent infusions
Busulfan (IV busulfex: PO Myleran) - ANSWER-Alkylating Agent
IV or PO
CML and Stem cell prep
Side effects - profound tachycardia, HTN, chest pain, hyperpigmentation,
alopecia, infertility, confusion, suizures, mucositis, nausea, vomiting, insomnia,
hyperglycemia, blurred vision, secondary malignancy, VOD (now sinusoidal
obstruction syndrome)
seizure prophylaxis
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