Exam (elaborations)
Pharmacology-USMLE-Step 1 Solutions.
Pharmacology-USMLE-Step 1 Solutions.
[Show more]
Seller
Follow
Content preview
Pharmacology-USMLE-Step 1 SolutionsNeutropenia - ANS-A common side effects of Interferon (INF) treatment is?
TMP-SMZ - ANS-Antimicrobial prophylaxis for a history of recurrent UTIs
Ceftriaxone - ANS-Antimicrobial prophylaxis for Gonorrhea
Rifampin (DOC), minocycline - ANS-Antimicrobial prophylaxis for
Meningococcal infection
TMP-SMZ (DOC), aerosolized pentamidine - ANS-Antimicrobial prophylaxis for PCP
Benzathine penicillin G - ANS-Antimicrobial prophylaxis for Syphilis Yes - ANS-Are
Aminoglycosides Teratogenic?
No - ANS-Are Ampicillin and Amoxicillin penicillinase resistant?
No - ANS-Are Carbenicillin, Piperacillin, and Ticarcillin penicillinase resistant?
No, but they are less susceptible than the other Beta lactams - ANS-Are
Cephalosporins resistant to penicillinase?
Yes - ANS-Are Methicillin, Nafcillin, and Dicloxacillin penicillinase resistant?
Mycobacterium tuberculosis, the only agent used as solo prophylaxis against TB -
ANS-Clinical use of Isoniazid (INH)?
Pseudomembranous colitis (C. difficile), fever, diarrhea - ANS-Common side effects
associated with Clindamycin include?
GI upset, Superinfections, Skin rashes, Headache, Dizziness - ANS-Common toxicities
associated with Fluoroquinolones?
Teratogenic, Carcinogenic, Confusion, Headaches - ANS-Common toxicities associated
with Griseofulvin?
,Glycoproteins from leukocytes that block various stages of viral RNA and DNA
synthesis - ANS-Describe the MOA of Interferons (INF)
Only in limited amounts - ANS-Do Tetracyclines penetrate the CNS?
AmOxicillin has greater Oral bioavailability - ANS-Does Ampicillin or Amoxicillin have a
greater oral bioavailability?
No - ANS-Does Amprotericin B cross the BBB?
No - ANS-Does Foscarnet require activation by a viral kinase?
Nephrotoxicity - ANS-Foscarnet toxicity?
Leukopenia, Neutropenia, Thrombocytopenia, Renal toxicity -
ANS-Ganciclovir associated toxicities?
Chronic Hepatitis A and B, Kaposi's Sarcoma - ANS-How are Interferons (INF) used
clinically?
Gram +, Gram -, Norcardia, Chlamydia - ANS-How are Sulfonamides employed
clinically?
Triple Therapy' 2 Nucleoside RT Inhibitors with a Protease Inhibitor - ANS-How are the
HIV drugs used clinically?
Primaquine - ANS-How are the Latent Hypnozoite (Liver) forms of Malaria (P. vivax,
P.ovale) treated?
Pyridoxine (B6) administration - ANS-How can Isoniazid (INH)-induced neurotoxicity be
prevented?
Fast vs. Slow Acetylators - ANS-How can the t1/2 of INH be altered? With
supplemental Folic Acid - ANS-How can the toxic effects of TMP be ameliorated?
Pretreat with antihistamines and a slow infusion rate - ANS-How can
Vancomycin-induced 'Red Man Syndrome' be prevented?
,As PABA antimetabolites that inhibit Dihydropteroate Synthase, Bacteriostatic -
ANS-How do Sulfonamides act on bacteria?
Inhibt Assembly of new virus by Blocking Protease Enzyme - ANS-How do the Protease
Inhibitors work?
Ganciclovir is more toxic to host enzymes - ANS-How does Ganciclovir's toxicity relate
to that of Acyclovir?
With an amino acid change of D-ala D-ala to D-ala D-lac - ANS-How does resistance to
Vancomycin occur?
HSV, VZV, EBV, Mucocutaneous and Genital Herpes Lesions, Prophylaxis in
Immunocompromised pts - ANS-How is Acyclovir used clinically?
Prophylaxis for Influenza A, Rubella; Parkinson's disease - ANS-How is Amantadine
used clinically?
Intrathecally - ANS-How is Amphotericin B administered for fungal meningitis?
Wide spectrum of systemic mycoses: Cryptococcus, Blastomyces, Coccidioides,
Aspergillus, Histoplasma, Candida, Mucor - ANS-How is Amphotericin B used clinically?
Meningitis (H. influenza, N. meningitidis, S. pneumoniae), Conserative treatment due to
toxicities - ANS-How is Chloramphenical used clinically?
CMV Retinitis in IC pts when Ganciclovir fails - ANS-How is Foscarnet used clinically?
Phosphorylation by a Viral Kinase - ANS-How is Ganciclovir activated? CMV, esp in
Immunocompromised patients - ANS-How is Ganciclovir used clinically? Oral
treatment of superficial infections - ANS-How is Griseofulvin used clinically?
Pentavalent Antimony - ANS-How is Leishmaniasis treated?
for RSV - ANS-How is Ribavirin used clinically?
1. Mycobacterium tuberculosis 2. Delays resistance to Dapsone when used of Leprosy
, 3. Used in combination with other drugs - ANS-How is Rifampin used clinically?
Used in combination therapy with SMZ to sequentially block folate synthesis - ANS-How
is Trimethoprim used clinically?
For serious, Gram + multidrug-resistant organisms - ANS-How is Vancomycin used
clinically?
Suramin - ANS-How would you treat African Trypanosomiasis (sleeping sickness)?
Premature infants, because they lack UDP-glucuronyl transferase - ANS-In what
population does Gray Baby Syndrome occur? Why?
No - ANS-Is Aztreonam cross-allergenic with penicillins?
Yes - ANS-Is Aztreonam resistant to penicillinase?
No - ANS-Is Aztreonam usually toxic?
Yes - ANS-Is Imipenem resistant to penicillinase?
No - duh - ANS-Is Penicillin penicillinase resistant?
Penicillin-G - ANS-IV Penicillin
Foscarnet = pyroFosphate analog - ANS-Mnemonic for Foscarnet?
1)Binds penicillin-binding proteins 2) Blocks transpeptidase cross- linking of cell wall 3)
Activates autolytic enzymes - ANS-MOA for Penicillin (3 answers)?
Penicillin, Cephalosporins, Vancomycin, Aminoglycosides,
Fluoroquinolones, Metronidazole - ANS-MOA: Bactericidal antibiotics
Penicillin, Ampicillin, Ticarcillin, Pipercillin, Imipenem, Aztreonam, Cephalosporins -
ANS-MOA: Block cell wall synthesis by inhib. Peptidoglycan cross-linking (7)
Quinolones - ANS-MOA: Block DNA topoisomerases
Rifampin - ANS-MOA: Block mRNA synthesis
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller modocko752. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £6.55. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
67096 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy revision notes and other study material for 14 years now