Immunology Kuby Chapter 3 Receptors
and Signaling: B and T-Cell Receptors
1. Which of the following types of bonds would be LEAST likely in a receptor-ligand
interaction?
A. Ionic bond
B. Covalent bond
C. Hydrogen bond
D. Hydrophobic interaction
E. Ionic bond - ANS-Answer: B
10. Which transcription factor becomes translocated to the nucleus downstream of
calmodulin activation?
A. NF-κB
B. NFAT
C. STAT1
D. STAT2
E. STAT3 - ANS-Answer: B
11. G proteins:
A. bind GTP.
B. dephosphrylate ITAMs.
C. are transcription factors.
D. downmodulate immune responses.
E. are adhesion molecules. - ANS-Answer: A
12. Which of the following is responsible for IL-2 expression in T cells?
A. NF-κB
B. NFAT
C. AP1
D. Both A and B
E. All of the above - ANS-Answer: E
13. Immunoglobulin domains consist of:
, A. series of α helices bound together by hydrophobic interactions in their side chains.
B. α helices alternating with parallel β-pleated sheets.
C. anti-parallel β-pleated sheets folded and stabilized by hydrophobic interactions.
D. compact, parallel β sheets forming a barrel structure.
E. α helices held together by leucine repeats. - ANS-Answer: C
14. On the gel below, which bands would you expect to bind antigen?
A. A
B. B
C. C
D. D
E. A, B, and C - ANS-Answer: E
15. Antibodies consist of:
A. two identical heavy chains and two identical light chains.
B. an α chain, a β chain, a λ chain, and a κ chain.
C. two α chains, an α chain, and a κ chain.
D. two β chains, an α chain, and a κ chain.
E. either an α chain or a β chain, a κ chain and a λ chain. - ANS-Answer: A
17. An antibody's idiotype refers to:
A. the kind of Fc region it contains.
B. the sequence of its CDR.
C. Ii's allelic form.
D. whether it is membrane bound or secreted.
E. which accessory molecules associate with it. - ANS-Answer: B
18. Carbohydrate chains attached to the CH2 domains of IgA, IgD, and IgG are believed
to:
A. allow for closer contact between partner chains.
B. confer stability to the molecule resulting in a higher desaturation temperature.
C. prevent protease degradation.
D. provide space for complement protein binding.
E. increase binding affinity for antigen. - ANS-Answer: D
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