Exam (elaborations)
Kuby Immunology Chapter 7.
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- ARRT CI Exam Study Guide
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- ARRT CI Exam Study Guide
Kuby Immunology Chapter 7.
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Kuby Immunology Chapter 7A mutation in which part of a viral protein might allow the virus to evade the adaptive
immune response because of MHC binding?
A. a TCR constant residue
B. a residue in the transmembrane domain of an envelope protein
C. a residue in the DNA-binding domain
D. an anchor residue
E. an amino acid on the surface of the virus - ANS-D. an anchor residue
Class II MHC molecules are _______.
A. homodimers; both subunits are derived from either the maternal of paternal
chromosome
B. heterodimers; one alpha subunit and one beta subunit
C. heterodimers; one subunit from the maternal chromosome and one from the
maternal genome
D. homodimers; composed of two alpha or two beta subunits - ANS-B. heterodimers;
one alpha subunit and one beta subunit
How many different MHC classical class I proteins does each nucleated cell in a human
heterozygous at the MHC locus express?
A. None, only APC express class I
B. one
C. two
D. three
E. six - ANS-E. six
, In an outbred population, which of the following individuals is most likely to be
histocompatible?
A. a parent
B. a sibling
C. a close-friend
D. a spouse - ANS-B a sibling
In people infected with human cytomegalovirus, class I MHC and b2-microglobulin are
produced, but very little mature class I MHC is found at the cell surface. Inhibition of
which of the following molecules by human cytomegalovirus may account for this
phenomenon?
A. TCR
B. RAG
C. CLIP
D. TAP
E. li - ANS-D. TAP
Lipids derived from pathogens can serve as T-cell antigens. When this occurs the lipids
are presented to TCRs via which molecule?
A. MHC I
B. MHC II
C. CD40
D. CD1 - ANS-D. CD1
MHC diversity ultimately affects the:
A. variety of peptides that bind to MHC
B. variety of BCRs that are expressed on mature B cells
C. rate of somatic hypermutation
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