Exam (elaborations)
Bio D103 Final
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- 11 Body Systems (Anatomy & Physiology
Exam of 6 pages for the course 11 Body Systems (Anatomy & Physiology at 11 Body Systems (Anatomy & Physiology (Bio D103 Final)
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Bio D103 FinalWhich of the following processes in the cell cycle would be most likely to be affected by
loss of the molecular motor myosin II? - ANS-Cell division
Which of the following conditions would block cytokinesis? - ANS-Inhibition of the
translocation of GEF protein to the midbody
Which of the following is NOT a feature of cells undergoing apoptosis? - ANS-Ligation
of DNA fragment
Which of the following genetically engineered proteins could protect cells from activating
the cell-extrinsic pathway of programmed cell death when expressed in mammalian
cells? - ANS-A Fas death receptor lacking the cytoplasmic region of the protein
Which of the following order of events most commonly occurs with the cell-intrinsic
pathway of apoptosis? - ANS-1) Change in activity of BCL2 proteins -> 2) formation of
channels in mitochondrial membranes -> 3) activation of downstream caspases -> 4)
cleavage of cellular proteins and DNA.
Based on your knowledge of cellular signaling you are asked to develop a strategy to
inhibit tumor growth in cancer patients whose tumors have a mutation of Ras. Which of
the following changes in gene expression might produce the best strategy? -
ANS-Inhibit Raf and Mek (MAP2K)
Which of the following events is NOT an important trait of a successful cancer cell? -
ANS-Enter into G0 phase
Which of the following proteins is NOT encoded by an oncogene? - ANS-PTEN
In general, which of the following barriers to metastasis is the easiest to overcome for
cancer cells? - ANS-Translocation from original tissue to a foreign tissue through blood
If a cell is detected with non-replicated or damaged DNA immediately before mitosis,
what would be an efficient way to delay entry into mitosis until repairs to the DNA has
been made? - ANS-Reversibly inhibits Cdc25
, Which of the following changes in gene expression could overcome an abnormal cell
cycle in fission yeast caused by the excess of CDC25 activity? - ANS-Increase Wee1
activity
How are cohesins removed from the arms of sister chromatids prior to metaphase in
mitosis? - ANS-By action of a kinase
A cell has been subjected to X-ray irradiation, causing a significant number of mutations
in the genome. Which of the following events would you NOT expect to occur as a result
of it? - ANS-Increased binding of p53 to Mdm2
Which of the following defects is most likely to be found in yeast cells with a dramatically
increased rate of genomic mutation per cell cycle? - ANS-An inactivating mutation within
a gene encoding an essential component of a DNA damage checkpoint
Which of the following processes in mitosis is NOT involved M-cyclin/CDK complex? -
ANS-Attachment of microtubule to kinetochore
Indicate whether each of the following phosphorylation events typically activates (A) or
inactivates (I) the protein that is being phosphorylated?
1) Phosphorylation of Cdc25 by M-cyclin/CDK
2) Phosphorylation of lamin subunits by M-cyclin/CDK
3) Phosphorylation of APC/C by M-cyclin/CDK
4) Phosphorylation of Ndc80 subunits by Aurora-B - ANS-A-I-A-I
Which stages of the cell cycle are absent from cells during early embryonic
development of Xenopusfrog embryos? - ANS-G0 and G2
What type of cell-cycle checkpoint defect might be found in mammalian cells whose size
become progressively smaller with each cell cycle? - ANS-Inactivation of an
environmental checkpoint working through G1-CDK
Which of the following statements best describes an example of positive feedback that
occurs during cell cycle? - ANS-Stimulation of transcription of E2F gene
What are the roles of a cyclin in regulation of CDK during the cell cycle?
1)Activate a CDK
2)Direct a CDK to its targets
3)Inhibit a CDK
4)Control CDK activity through the phosphorylation of cyclin
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