Unlock your academic potential with my notes on Immunity and Infection, tailored specifically for students pursuing Biomedical Science, Biochemistry, Immunology, Biology, Biomedical Engineering and Nursing. These notes are perfect for anyone looking to excel in their studies and gain a deep underst...
Lecture: Infection and Immunity
Date: Thursday 1st February
Time: 11am – 12pm
Adaptive Immunity
The role of antibody and T cells in the adaptive immune response to pathogens. We are
going to discuss the start of adaptive immunity, starting from the big bang. We will discuss
their development, what antibodies see on the surface of the antigen, and compare that to t
cells in antigenic peptides. We will also discuss invasion of antibodies, giving examples of
parasites, bacteria, and viruses.
Key words
Fab – fraction antigen binding
Fc – Fraction crystallizable.
There is a variable region of the light chain and the heavy chain, which come together to
form a 3-dimensional structure of a lute protein. The structure of the T cell receptor is
presented on MHC. This evolved 500 million years ago:
organised areas of lymphoid tissue
Highly specified t cell receptors
Highly specific antibody molecules
Memory of previous encounter – both b cells and t cells develop into memory cells
i.e. recognising covid-19 and will search for the site of infection before you become
ill.
How do we produce an antibody?
We need 10 to 11 antibodies to deal with pathogens, put pieces of genes together to
produce a new specificity each time.
B-Cells
1) In the bone barrow t cells arrange themselves to form b cell precursor
2) B cell bound to self-cell surface antigen is removed from the repertoire. Destroys self-
reactive cells by apoptosis.
3) Other cell types that don’t recognise self can leave the bone marrow to go find
potential antigens. B cell has antibodies on cell surface to identify multivalent foreign
body.
4) Activated B cells give rise to plasma cells and memory cells. These memory cells go
into the bone marrow and wait for the infection to return.
T cells – made in the bone barrow but migrate to the thymus.
1
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller morgan_helene. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for £10.49. You're not tied to anything after your purchase.
