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GNUR 293, Module 5.
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Exam of 2 pages for the course Anatomy Condensed Final Exam Review - GNUR 155 at Anatomy Condensed Final Exam Review - GNUR 155 (GNUR 293, Module 5.)

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  • June 15, 2024
  • 2
  • 2023/2024
  • Exam (elaborations)
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GNUR 293, Module 5
Hypersensitivity reaction - ANS-Altered immune response to antigen, an excessive or
inappropriately triggered immune response resulting in tissue damage or abnormal cell
function (allergy, autoimmunity, alloimmunity)

Allergy - ANS-Hypersensitivity to environmental (exogenous) antigens

Autoimmunity - ANS-Lack of immunologic tolerance of self-antigens

Alloimmunity - ANS-Immune reaction to tissues of another individual

Types of hypersensitivity immune mechanism - ANS-Type I: IgE mediated (genetic
predisposition)
Type II: Tissue-specific reactions
Type III: Immune complex mediated
Type IV: Cell mediated

Type I hypersensitivity - ANS-IgE mediated
effector cell: mast cells
antibody: IgE
onset: immediate
example: seasonal allergies

Type II hypersensitivity - ANS-Tissue-specific reactions
effector cell: tissue macrophages
antibody: IgG, IgM
onset: immediate
example: Grave's disease, Purpura, blood transfusion reaction, myasthenia gravis

Type III hypersensitivity - ANS-Immune complex-mediated
effector cell: neutrophils
antibody: IgG, IgM
onset: immediate
example: Lupus (SLE), Raynaud's, glomerulonephritis

Type IV hypersensitivity - ANS-Cell mediated
effector cell: lymphocytes, macrophages
antibody: none

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