* Decreased HR and contractility r/t slower AV conduction system & prolonged the refractory
period
*Decreased BP r/t decreased cardiac output
*Slows renin release due to decreased sympathetic peripheral outflow (carteolol, labetolol,
and pindolol do not consistently inhibit renin release)
Beta receptors (found in heart and stimulation from catecholamines causes an increased
HR, BP, contractility & av conduction and decrease av node refractory period)
, adverse effects associated with SSRIs - correct answer-anxiety, agitation, anorexia, GI
distress, headache, hypotension, sexual dysfunction
Nausea, decreased sexual function, weight gain
Serotonin syndrome: hyperacticity, tachycardia, hypertension, tremors, GI upset, sweating,
AMS, fever agitation, myoclonus, hyperthermia (will occur within 24hrs, treated with
supportive care)
Hyperthermia is hallmark sign according to ppt
Headache
*Sweating
*Anxiety and Agitation
*GI effects (n/v/d)
*Changes in weight
*Weakness and fatigue
*Sleep disturbances (insomnia or somnolence)
*Sexual dysfunction
*Serotonin Syndrome
*SIADH
*Bruxism (grinding, clenching, or gnashing of teeth)
Anti-depressant actions SSRI's and SNRI's - correct answer-All current antidepressants act
on neurotransmitter systems by affecting three distinct processes: neurotransmitter
degradation, neurotransmitter reuptake, and neurotransmitter binding.
• Degradation of all three neurotransmitter is accomplished by monoamine oxidase (MAO)
enzyme. The catechol-O-methyltransferase (COMT) enzyme degrades norepinephrine and
dopamine
• Another mechanism of action of antidepressants involves inhibiting the reuptake of
neurotransmitters in the synapse. Neurotransmitters are removed from the synapse by
reuptake pump on the presynaptic neuron. Inhibiting this reuptake enhances the amount of
transmitter in the synapse.
• The third mechanism of action of antidepressants involves neurotransmitter receptor
binding sensitization. This is a delayed effect.
• SSRIs: work by increasing the amount of serotonin by blocking the presynaptic serotonin
reuptake pump. There are at least 14 different postsynaptic serotonin receptors present in
humans. Each one controls a different physiological and/or psychiatric function. The action
of SSRIs depends on which postsynaptic receptor is stimulated. It is believed that receptor
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