Activated partial thromboplastin time (aPTT) - correct answer-Screens for intrinsic and
common pathways
- all Factors except VII and XIII
- Monitor Heparin therapy
-Reagent: Activator (kaolin, celite or ellagic acid), platelet phospholipid and CaCl2
RI: 25-35seconds
Therapeutic goal: 1.5-2.5 * normal
Acute blood Los - correct answer-Normocytic/Normochromic anemia
Normal BM, increased retics
Acute Lymphocytic Leukemia (ALL) and Lymphoma - correct answer-A. Classified as same
disease with different clinical presentations
B. Either B or T according to cell lineage
C. Peripheral blood and BM involvement with>20% blasts defines ALL
D. Solid tumor presentation defines lyphoma
Adult Hematopoiesis - correct answer-Skull, sternum, pelvis, ribs and vertebrae.
Flat bones: active adult hemopoietic tissue (colony forming units in red marrow)
,Alder-Reilly Anomaly - correct answer-Characteristics: Large azurophilic granules
Antiphospholipid syndrome - correct answer-Any of the three classes of antibodies.
Anticardiolipin antibodies. Lupus anticoagulant. Specific antibodies.
Antithrombin - correct answer--Principle antagonist of active coagulation proteases.
---Produced in the liver.
-Activated by heparin sulfate on the endothelial cell and by heparin as a therapeutic drug.
Aplastic Anemia - correct answer-a normocytic-normochromic type of anemia characterized
by the failure of bone marrow to produce red blood cells
- Dry Tap bone marrow, hypocellular BM, decreased retics, pancytopenia
N-Increased serum ferritin, Decreased serum Iron
Decreased TIBC
Chronic Lymphocytic Leukemia (CLL) - correct answer-abnormal numbers of relatively
mature lymphocytes predominate in the marrow, lymph nodes, and spleen
- Decreased LAP, philadelphia chromosome (bcr/abl)
Clot busters - correct answer--streptokinase
-tpa=tissue plasminogen activator that convert inactive plasminogen into plasmin
-Urokinase
Clot Retraction - correct answer-1. Evaluates platelet function, fibrinogen, red cell volume
and fibrinolytic activity
2. Abnormal if platelet count < 100 x 10^9 /L
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